Risk factors of nosocomial infection in patients underwent artificial liver support system: a retrospective case-control study

作者全名："Zhang, Xu; Qin, Deyu; Liu, Guangwei; Li, Feng; Peng, Jingjing; Xiang, Yanling"

作者地址："[Zhang, Xu; Liu, Guangwei; Li, Feng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Qin, Deyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Chongqing, Peoples R China; [Peng, Jingjing] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China; [Xiang, Yanling] Chongqing Med Univ, Univ Town Hosp, Dept Surg & Anesthesiol, Chongqing, Peoples R China; [Liu, Guangwei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400042, Peoples R China"

通信作者："Liu, GW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400042, Peoples R China."

来源：EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000980172100013

JCR分区：Q3

影响因子：2.3

年份：2023

卷号：35

期号：5

开始页：604

结束页：608

文献类型：Article

关键词：artificial liver; case; control study; logistic models; nosocomial infection; risk factors

摘要："BackgroundAlthough nosocomial infection is one of the most discussed problems in patients undergoing artificial liver support system (ALSS) treatment, only few solutions have been proposed so far. This study aimed to explore the risk factors of nosocomial infection in patients treated with ALSS in order to aid in the development of future preventive measures. MethodsThis retrospective case-control study included patients treated with ALSS at the Department of Infectious Diseases, First Affiliated Hospital of xxx Medical University between January 2016 and December 2021. ResultsOne hundred seventy-four patients were included. There were 57 patients in the nosocomial infection group and 117 patients in the non-nosocomial infection group, of them 127 males (72.99%) and 47 females (27.01%) with an average age of 48.15 +/- 14.19 years old. Multivariate logistic regression analysis revealed that total bilirubin [odds ratio (OR) = 1.004; 95% confidence interval (CI), 1.001-1.007; P = 0.020], number of invasive procedures (OR = 2.161; 95% CI, 1.500-3.313; P < 0.001), blood transfusion (OR = 2.526; 95% CI, 1.312-4.864; P = 0.006) were independent risk factors and haemoglobin (Hb) (OR = 0.973; 95% CI, 0.953-0.994; P = 0.011) was a protective factor for nosocomial infection in patients treated with ALSS. ConclusionThe total bilirubin, transfusion of blood products and higher number of invasive operations were independent risk factors for nosocomial infection in patients treated with ALSS, while higher Hb was a protective factor."

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