The Effect of Bilirubin on Clinical Outcomes of Patients With Colorectal Cancer Surgery: A Ten-Year Volume Single-Center Retrospective Study

作者全名："Li, Zi-Wei; Zhang, Bin; Liu, Xiao-Yu; Kang, Bing; Liu, Xu-Rui; Yuan, Chao; Wei, Zheng-Qiang; Peng, Dong"

作者地址："[Li, Zi-Wei; Zhang, Bin; Liu, Xiao-Yu; Liu, Xu-Rui; Yuan, Chao; Wei, Zheng-Qiang; Peng, Dong] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Kang, Bing] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 1, Chongqing, Peoples R China; [Peng, Dong] Hosp Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated 1, Chongqing 400016, Peoples R China"

通信作者："Peng, D (通讯作者)，Hosp Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated 1, Chongqing 400016, Peoples R China."

来源：NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000980338400001

JCR分区：Q3

影响因子：2

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Article; Early Access

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摘要："The current study aimed to evaluate the effect of bilirubin on the outcomes of colorectal cancer (CRC) in patients who underwent radical CRC surgery. The levels of serum bilirubin, including total bilirubin (TBil), direct bilirubin (DBil) and indirect bilirubin (IBil), were divided into higher groups and lower groups according to the median. Multivariate logistic regression was performed to analyze the independent predictors for overall complications and major complications. For TBil, the hospitalization time of the higher TBil group was longer than that of the lower TBil group (p = 0.014 < 0.05). For DBil, the higher DBil group had longer operation times (p < 0.01), more intraoperative bleeding (p < 0.01), longer hospital stays (p < 0.01), and higher rates of overall complications (p < 0.01) and major complications (p = 0.021 < 0.05) than the lower DBil group. For the IBil group, blood loss during operation (p < 0.01) and hospital stays (p = 0.041 < 0.05) in the higher IBil group were lower than those in the lower IBil group. In terms of complications, we found that DBil was an independent predictor for overall complications (p < 0.01, OR = 1.036, 95% CI = 1.014-1.058) and major complications (p = 0.043, HR= 1.355, 95% CI= 1.009-1.820). Higher preoperative DBil increase the risk of complications after primary CRC surgery."

基金机构：Chongqing key diseases Research and Application Demonstration Program (Colorectal Cancer Prevention and Treatment Technology Research and Application Demonstration) [2019ZX003]

基金资助正文：This study was supported by Chongqing key diseases Research and Application Demonstration Program (Colorectal Cancer Prevention and Treatment Technology Research and Application Demonstration [No. 2019ZX003]).