Microbiota-derived short-chain fatty acids may participate in post-stroke depression by regulating host?s lipid metabolism

作者全名："Jiang, Wenxia; Chen, Jianjun; Gong, Lei; Liu, Fang; Zhao, Huan; Yan, Zhiwen; Li, Yingli; Zhang, Jie; Xiao, Mi; Mu, Jun"

作者地址："[Jiang, Wenxia; Gong, Lei; Liu, Fang; Zhao, Huan; Yan, Zhiwen; Li, Yingli; Zhang, Jie; Xiao, Mi; Mu, Jun] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing, Peoples R China"

通信作者："Mu, J (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing, Peoples R China."

来源：JOURNAL OF PSYCHIATRIC RESEARCH

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000980666500001

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：161

期号：　

开始页：426

结束页：434

文献类型：Article

关键词：Post -stroke depression; Prefrontal cortex; Lipid metabolism; Short chain fatty acids; Microbiota-gut-brain axis

摘要："Background: Post-stroke depression (PSD) is a common mental disorder of stroke survivors, its pathogenesis remains elusive. Previous studies suggested a role of the microbiota-gut-brain (MGB) axis in stroke and depression. In this study, we characterized microbial composition and function, and gut-brain metabolic signatures, in PSD rats. We aim to explore how disordered gut microbes participate in the pathogenesis of PSD through the MGB axis. Materials and methods: 16S rRNA gene sequence and fecal metabolome analysis were performed to identify the gut microbiome and their functional metabolites in PSD rats. Then, the lipid metabolic signatures in the prefrontal cortex (PFC) of PSD were conducted by liquid chromatography mass spectrometry. Finally, the potential pathway between gut and brain in the onset of PSD were explored. Results: Compared to control and stroke rats, there were 10 genera (most of them belonged to phylum Firmicutes) significantly changed and 3 short chain fatty acids (SCFAs: butyric acid, acetic acid and pentanoic acid) significantly decreased in PSD rats. Meanwhile, altered gut microbial in PSD rats was significantly associated with these SCFAs. Compared with control and stroke rats, 57 lipid metabolites in the PFC of PSD rats were significantly changed. In addition, the altered SCFAs in PSD rats were also significantly correlated with most of disordered lipid metabolites in PFC. Conclusions: Our findings suggest that the SCFAs may be a bridge of gut-brain communication. The FirmicutesSCFAs-lipid metabolism might be a potential pathway to further investigate the MGB axis and pathogenesis of PSD."

基金机构：National Natural Science Foundation of China [81371310]; Science and Technology Committee of Chongqing [cstc2018jcyjAX0130]; Chongqing Health Com-mission [2020MSXM038]

基金资助正文："This article was funded by National Natural Science Foundation of China (Grant No. 81371310) , Science and Technology Committee of Chongqing (Grant No. cstc2018jcyjAX0130) , Chongqing Health Com-mission (Grant No. 2020MSXM038) ."