Upconversion Nanoplatform Enables Multimodal Imaging and Combinatorial Immunotherapy for Synergistic Tumor Treatment and Monitoring

作者全名："Gu, Mengqin; Zhang, Linglin; Hao, Liying; Wang, Kun; Yang, Wei; Liu, Zhenqi; Lei, Zixue; Zhang, Yinmo; Li, Wei; Jiang, Li; Li, Xiyu"

作者地址："[Gu, Mengqin; Zhang, Linglin; Hao, Liying; Wang, Kun; Yang, Wei; Liu, Zhenqi; Lei, Zixue; Zhang, Yinmo; Li, Wei; Jiang, Li; Li, Xiyu] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China; [Gu, Mengqin; Zhang, Linglin; Hao, Liying; Wang, Kun; Yang, Wei; Liu, Zhenqi; Lei, Zixue; Zhang, Yinmo; Li, Wei; Jiang, Li; Li, Xiyu] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China; [Gu, Mengqin] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing 401147, Peoples R China; [Jiang, Li] Sichuan Univ, West China Hosp Stomatol, Dept Gen Dent, Chengdu, Peoples R China"

通信作者："Jiang, L; Li, XY (通讯作者)，Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.; Jiang, L; Li, XY (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China.; Jiang, L (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Dept Gen Dent, Chengdu, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000982465100001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：upconversion; hydroxyapatite; multimodal imaging; synergistic therapy; immunogenic cell death; oral squamous cell carcinoma

摘要："Designing a novel nanoplatform that integrates multimodal imaging and synergistic therapy for precision tumor nanomedicines is challenging. Herein, we prepared rare-earth ion-doped upconversion hydroxyapatite (FYH) nanoparticles as nanocarriers coated and loaded respectively with polydopamine (PDA) and doxorubicin (DOX), i.e., FYH-PDA-DOX, for tumor theranostics. The developed FYH-PDA-DOX complexes exhibited desirable photothermal conversion, pH/nearinfrared-irradiation-responsive DOX release, and multimodal upconversion luminescence/computed tomography/magnetic resonance imaging performance and helped monitor the metabolic distribution process of the complexes and provided feedback to the therapeutic effect. Upon 808 nm laser irradiation, the fast release of DOX facilitated the photothermal-chemotherapy effect, immunogenic cell death, and antitumor immune response. On combining with the anti-programmed cell death 1 ligand 1 antibody, an enhanced tri-mode photothermal-chemo-immunotherapy synergistic treatment against tumors can be realized. Thus, this treatment elicited potent antitumor immunity, producing appreciable T-cell cytotoxicity against tumors, amplifying tumor suppression, and extending the survival of mice. Therefore, the FYH-PDA-DOX complexes are promising as a smart nanoplatform for imaging-guided synergistic cancer treatment."

基金机构："National Key R&D Program of China [2021YFA1201302]; National Natural Science Foundation of China [32071335]; Miaozi Project in Science and Technology Innovation Program of Sichuan Province [2022080]; Postdoctoral Science Foundation of China [2022M720614]; Science and Technology Department of Sichuan Province for Distinguished Young Scholars [2023NSFSC1930]; West China School/Hospital of Stomatology, Sichuan University [RCDWJS2020-9]"

基金资助正文："This work was supported by the National Key R & D Program of China (Grant No. 2021YFA1201302), the National Natural Science Foundation of China (Grant No. 32071335), Miaozi Project in Science and Technology Innovation Program of Sichuan Province (Grant No. 2022080), the Postdoctoral Science Foundation of China (Grant No. 2022M720614), Science and Technology Department of Sichuan Province for Distinguished Young Scholars (Grant No. 2023NSFSC1930), and the Research Funding from West China School/Hospital of Stomatology, Sichuan University (Grant No. RCDWJS2020-9)."