Injectable Self-Setting Ternary Calcium-Based Bone Cement Promotes Bone Repair

作者全名："Cheng, Shengwen; Zhao, Chen; Liu, Senrui; Chen, Bowen; Chen, Hong; Luo, Xuefeng; Wei, Li; Du, Chengcheng; Xiao, Pengcheng; Lei, Yiting; Yan, Yonggang; Huang, Wei"

作者地址："[Cheng, Shengwen; Zhao, Chen; Liu, Senrui; Chen, Bowen; Luo, Xuefeng; Wei, Li; Du, Chengcheng; Xiao, Pengcheng; Lei, Yiting; Huang, Wei] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Chen, Hong; Yan, Yonggang] Sichuan Univ, Coll Phys, Chengdu 610064, Peoples R China"

通信作者："Lei, YT; Huang, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Yan, YG (通讯作者)，Sichuan Univ, Coll Phys, Chengdu 610064, Peoples R China."

来源：ACS OMEGA

ESI学科分类：CHEMISTRY

WOS号：WOS:000985633900001

JCR分区：Q2

影响因子：3.7

年份：2023

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期号：　

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文献类型：Article; Early Access

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摘要："Bone defects, especially large ones, are clinically difficult to treat. The development of new bone repair materials exhibits broad application prospects in the clinical treatment of trauma. Bioceramics are considered to be one of the most promising biomaterials owing to their good biocompatibility and bone conductivity. In this study, a self-curing bone repair material having a controlled degradation rate was prepared by mixing calcium citrate, calcium hydrogen phosphate, and semi-hydrated calcium sulfate in varying proportions, and its properties were comprehensively evaluated. In vitro cell experiments and RNA sequencing showed that the composite cement activated PI3K/Akt and MAPK/Erk signaling pathways to promote osteogenesis by promoting the proliferation and osteoblastic differentiation of mesenchymal stem cells. In a rat model with femoral condyle defects, the composite bone cement showed excellent bone repair effect and promoted bone regeneration. The injectable properties of the composite cement further improved its practical applicability, and it can be applied in bone repair, especially in the repair of irregular bone defects, to achieve superior healing."

基金机构：project of Chongqing Municipal Education Commission [KJZD-M202100401]

基金资助正文：This research was supported by the major project of Chongqing Municipal Education Commission (KJZD-M202100401) .