Serum CA125 as a biomarker for dysmenorrhea in adenomyosis

作者全名："Tang, Ying; Wen, Ming-Bo; Xiang, Ru-Mei; Yang, Ming-Tao; Shu, Bin; Xu, Fan; Li, Jun; Hu, Hui-Quan; Shi, Qiuling"

作者地址："[Tang, Ying; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Tang, Ying; Wen, Ming-Bo; Yang, Ming-Tao; Shu, Bin; Xu, Fan; Li, Jun; Hu, Hui-Quan] North Sichuan Med Coll, Affiliated Nanchong Cent Hosp, Dept Obstet & Gynecol, Nanchong, Sichuan, Peoples R China; [Xiang, Ru-Mei] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing, Peoples R China"

通信作者："Shi, QL (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000986357200001

JCR分区：Q2

影响因子：2.6

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：adenomyosis; association; CA125; dysmenorrhea; inflammation; pathogenesis

摘要："ObjectiveTo explore the association between CA125 and dysmenorrhea in adenomyosis, and the factors affecting CA125 in adenomyosis. MethodsPatients were grouped a the presence of dysmenorrhea. The receiver operating characteristic (ROC) curve was applied to assess the utility of CA125 for dysmenorrhea. Binary logistic regression was employed to identify the factors associating dysmenorrhea and CA125 level. ResultsPatients in the dysmenorrhea group had higher CA125 levels than those in the non-dysmenorrhea group. For those with dysmenorrhea, CA125 levels of diffuse subtype group were higher than those of the focal subtype group. The CA125 level of 35 U/mL was validated as the optimal cut-point for dysmenorrhea in ROC curves. Compared with patients whose CA125 was 35 U/mL or less, those with CA125 levels greater than 35 U/mL were more likely to have dysmenorrhea. Thereafter, the multiple regression analysis showed that adenomyotic lesion volume was positively correlated with CA125 level in the total cohort and subtype groups, while age was negatively correlated with CA125 level in the total cohort and diffuse subtype. ConclusionsThe pathogenesis of adenomyosis is not clear. CA125 was associated with dysmenorrhea in adenomyosis, and, furthermore, CA125 level is positively correlated with the severity of the disease."

基金机构："Bureau of Science and Technology Nanchong City [20SXQT0320, 22SXQT0254, 22SXQT034]; State Key Laboratory of Scientific and Engineering Computing [2020KFKT003, 2021KFKT022]; General Program of National Natural Science Foundation [81872506]"

基金资助正文："Bureau of Science and Technology Nanchong City, Grant/Award Number: 20SXQT0320, 22SXQT0254 and 22SXQT034; State Key Laboratory of Scientific and Engineering Computing, Grant/Award Number: 2020KFKT003 and 2021KFKT022; General Program of National Natural Science Foundation, Grant/Award Number: 81872506"