"The relationship between peripheral blood soluble ST2, BNP levels, cardiac function, and prognosis in patients with heart failure"

作者全名："Gu, Di; Zhou, Jianzhong"

作者地址："[Gu, Di; Zhou, Jianzhong] Chongqing Med Univ, Dept Internal Med, Div Cardiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Zhou, JZ (通讯作者)，Chongqing Med Univ, Dept Internal Med, Div Cardiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000988957300021

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：15

期号：4

开始页：2878

结束页：2884

文献类型：Article

关键词：Heart failure; cardiac function; soluble growth-stimulated expression gene 2 protein; B-type natriuretic peptide; prognosis

摘要："Objective: To analyze the relationship between peripheral blood soluble growth-stimulated expression gene 2 protein (sST2) and B-type natriuretic peptide (BNP) levels and cardiac function and prognosis in patients with heart failure (HF). Methods: HF patients (n = 183) and 50 healthy volunteers were enrolled in this retrospective study. The relationships between peripheral blood sST2 and BNP levels and cardiac function in patients with HF were analyzed by Pearson's correlation analysis. HF patients were divided into a poor prognosis group (n = 25) and a good prognosis group (n = 158) during the 1-year follow-up period, and variables that might affect the prognosis of HF patients were screened by univariate analysis. Result: The peripheral blood sST2 and BNP levels of HF patients were higher than those of healthy controls. Compared to the good prognosis group, the poor prognosis group had higher LVDs, LVDd, but lower LVEF, D-dimer, hemoglobin (HB) levels, uric acid, sST2, BNP, troponin I (TnI), creatine kinase isozyme-MB, myoglobin, creatinine (Cr), and hypersensitive C-reactive protein. LVEF, sST2, BNP, TnI, and HB were independent risk factors affecting the prognosis of patients with HF. Higher levels of peripheral blood sST2 and BNP were associated with the worse prognosis in HF. Conclusion: Peripheral blood sST2 and BNP levels in HF patients were correlated with cardiac function. LVEF, sST2, BNP, TnI, and HB were independent risk factors affecting the prognosis of HF patients, among which sST2 and BNP were all negatively correlated with prognosis."

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