"Dietary polyunsaturated fatty acids intake, air pollution, and the risk of lung cancer: A prospective study in UK biobank"

作者全名："Chen, Ting; Song, Lingling; Zhong, Xiaoni; Zhu, Qian; Huo, Jiao; Chen, Jiahui; Tan, Sensen; Lian, Xuemei"

作者地址："[Chen, Ting; Song, Lingling; Zhong, Xiaoni; Zhu, Qian; Huo, Jiao; Chen, Jiahui; Tan, Sensen; Lian, Xuemei] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Chen, Ting; Huo, Jiao] Chongqing Ctr Dis Control & Prevent, Chongqing 400042, Peoples R China; [Zhu, Qian; Lian, Xuemei] Chongqing Med Univ, Affiliated Hosp 2, Ctr Lipid Res, Chongqing 400016, Peoples R China; [Zhu, Qian; Lian, Xuemei] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Minist Educ,Chongqing Key Lab Meta, Chongqing 400016, Peoples R China; [Chen, Ting; Song, Lingling; Zhong, Xiaoni; Zhu, Qian; Huo, Jiao; Chen, Jiahui; Tan, Sensen; Lian, Xuemei] Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing 400016, Peoples R China; [Lian, Xuemei] 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Lian, XM (通讯作者)，1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：SCIENCE OF THE TOTAL ENVIRONMENT

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000989106800001

JCR分区：Q1

影响因子：8.2

年份：2023

卷号：882

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Dietary polyunsaturated fatty acids; Air pollution; Lung cancer; Prospective cohort study

摘要："Background: Epidemiological evidence on the association between specific types of polyunsaturated fatty acids (PUFAs) intake and lung cancer risk is limited. However, whether dietary-specific PUFAs intake can modify the asso-ciation between air pollutants and incident lung cancer remains unknown. Methods: Cox proportional hazard models and restricted cubic spline regression were used to evaluate the associations of omega-3 PUFAs, omega-6 PUFAs and the ratio of omega-6 PUFAs to omega-3 PUFAs intake with lung cancer risk. Furthermore, we evaluated the associations between air pollutants and incident lung cancer, and whether dietary -specific PUFAs intake would modify the relationship using stratification analyses. Results: This study found significant associations between the risk of lung cancer and omega-3 PUFAs intake (hazard ratio [HR], 0.82; 95 a/o confidence interval [CI], 0.73-0.93; per 1 g/d), and omega-6 PUFAs intake (HR, 0.98; 95 a/o CI, 0.96-0.99; per 1 g/d). We did not observe an association between the omega-6 to omega-3 PUFAs intake ratio and incident lung cancer. With regard to air pollution, omega-3 PUFAs intake attenuated the positive relationship be-tween nitrogen oxides (NOx) pollution and lung cancer risk, and an increased incidence of lung cancer was found only in the low omega-3 PUFAs intake group (p < 0.05). Surprisingly, PUFAs intake (regardless of omega-3 PUFAs, omega-6 PUFAs, or in total) reinforced the pro-carcinogenic effects of PM2.5 on lung cancer, and a positive association between PM2.5 pollutants and incident lung cancer was observed only in the high PUFAs groups (p < 0.05). Conclusions: Higher dietary omega-3 and omega-6 PUFAs intake was associated with a decreased risk of lung cancer in the study population. As omega-3 PUFAs have different modification effects on NOX and PM2.5 air pollution related lung cancer incidence, precautions should be taken when using omega-3 PUFAs as health-promoting dietary supple-ments, especially in high PM2.5 burden regions."

基金机构：National Natural Science Foundation of China [81973030]; CQMU Program for Youth Innovation in Future Medicine [W0085]; Chongqing Medical Scientific Research Project [2023MSXM064]

基金资助正文："Funding This work was funded by the National Natural Science Foundation of China (No. 81973030) , CQMU Program for Youth Innovation in Future Medicine (No. W0085) , Chongqing Medical Scientific Research Project (No. 2023MSXM064) ."