Long-term outcomes of ultrasound guided high intensity focused ultrasound ablation for patients with uterine fibroids classified by T2WI: a multicenter retrospective study

作者全名："Yuan, Yuan; Xu, Wei; Shen, Huangpin; Lin, Zhenjiang; Xu, Fan; Shi, Qiuling; Zhan, Ping; Liu, Mali; Shu, Jian; Chen, Jinyun; Xing, H. Rosie"

作者地址："[Yuan, Yuan; Shi, Qiuling; Chen, Jinyun; Xing, H. Rosie] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing 400016, Peoples R China; [Yuan, Yuan; Zhan, Ping] Southwest Med Univ, Sichuan Prov Ctr Gynaecol & Breast Dis, Affiliated Hosp, Luzhou, Peoples R China; [Xu, Wei; Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Shen, Huangpin] Chung Shan Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan; [Lin, Zhenjiang] Zunyi Med Univ, Dept Obstet & Gynecol, Affiliated Hosp, Zunyi, Peoples R China; [Xu, Fan] North Sichuan Med Univ, Nanchong Cent Hosp, Clin Med Coll 2, Dept Obstet & Gynecol, Nanchong, Peoples R China; [Liu, Mali; Shu, Jian] Southwest Med Univ, Dept Radiol, Affiliated Hosp, Luzhou, Peoples R China"

通信作者："Chen, JY; Xing, HR (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000989253800001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Uterine fibroids; ultrasound guided high-intensity focused ultrasound (USgHIFU); T2-weighted MRI; reintervention; long-term followed-up outcomes

摘要："Objective To evaluate the long-term outcomes of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids classified by T2-weighted magnetic resonance imaging (T2WI-MRI). Materials and methods The data of 1427 premenopausal women with symptomatic uterine fibroids who underwent USgHIFU at four teaching hospitals in China were analyzed retrospectively. The uterine fibroids were classified based on their T2WI-MRI signal intensities relative to that of skeletal muscle, myometrium and endometrium as: hypointense, isointense, heterogeneous hyperintense fibroids (HHF), slightly HHF (sHHF) and markedly HHF (mHHF), respectively. The rates of symptom relief and reintervention post-USgHIFU ablation were compared between the classified groups. Results A total of 1303 patients were followed up for 44 (40, 49) months. The symptom relief rate of the hypointense and isointense fibroids was 83.3% and 79.5%, respectively, which were significantly higher (p < .05) compared to that of HHF, sHHF and mHHF (58.3%, 44.2% and 60.4%), respectively. sHHF had the lowest symptom relief rate (p < .05). The cumulative reintervention rate for hypointense, isointense, HHF, sHHF and mHHF types were 8.8%, 10.8%, 21.4%, 39.9% and 19.8%, respectively. The reintervention rate of hypointense/isointense fibroids was significantly lower than that of HHF/mHHF/sHHF (p < .01), while sHHF had the highest re-intervention rate (p < .01). Thus, reintervention rate is inversely correlated to the rate of symptom relief. Conclusions USgHIFU ablation is effective for hypointense, isointense, HHF and mHHF with acceptable long-term follow-up outcomes. However, sHHF is associated with a higher reintervention rate."

基金机构：Luzhou Science and Technology Bureau [2022-SYF-57]

基金资助正文：This research was supported by the Luzhou Science and Technology Bureau under Grant [Fund code: 2022-SYF-57].