Immune responses to inactivated COVID-19 vaccine were decreased in Chinese patients with chronic respiratory diseases

作者全名："Yang, Lei; Xu, LingFang; Guo, Qiao; Deng, Bing; Hong, Yang; Wang, LiangLiang; Wang, YaLin; Jiang, DePeng; Ren, Hong"

作者地址："[Yang, Lei; Deng, Bing; Hong, Yang; Wang, LiangLiang; Wang, YaLin; Jiang, DePeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China; [Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ,Inst Viral, Chongqing, Peoples R China; [Xu, LingFang] Qingdao Univ, Affiliated Hosp, Dept Endocrinol & Metab, Qingdao, Peoples R China; [Guo, Qiao] Chongqing Med Univ, Affiliated Hosp 2, Dept Gen Med, Chongqing, Peoples R China"

通信作者："Jiang, DP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China.; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ,Inst Viral, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000994052700005

JCR分区：Q1

影响因子：3.2

年份：2023

卷号：20

期号：6

开始页：737

结束页：748

文献类型：Article

关键词：　

摘要："Purpose: The effectiveness of inactivated vaccines against acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has become a global concern. Hence, the aim of this study was to evaluate vaccine safety and to assess immune responses in individuals with chronic respiratory disease (CRD) following a two-dose vaccination.Methods: The study cohort included 191 participants (112 adult CRD patients and 79 healthy controls [HCs]) at least 21 (range, 21-159) days after a second vaccination. Frequencies of memory B cells (MBCs) subsets and titers of SARS-CoV-2 neutralizing antibodies (NAbs) and anti-receptor binding domainResults: As compared to the HCs, CRD patients had lower seropositivity rates and titers of both anti-RBD IgG Abs and NAbs, in addition to lower frequencies of RBD-specific MBCs (all, p < 0.05). At 3 months, CRD patients had lower seropositivity rates and titers of anti-RBD IgG Abs than the HCs (p < 0.05). For CoronaVac, the seropositivity rates of both Abs were lower in patients with old pulmonary tuberculosis than HCs. For BBIBP-CorV, the seropositivity rates of CoV-2 NAbs were lower in patients with chronic obstructive pulmonary disease than HCs (all, p < 0.05). Meanwhile, there was no significant difference in overall adverse events between the CRD patients and HCs. Univariate and multivariate analyses identified the time interval following a second vaccination as a risk factor for the production of anti-RBD IgG Abs and CoV-2 NAbs, while the CoronaVac had a positive effect on the titers of both Abs. Female was identified as a protective factor for CoV-2 NAb levels.Conclusion: Inactivated COVID-19 vaccines were safe and well tolerated by CRD patients but resulted in lower Ab responses and the frequencies of RBD-specific MBCs. Therefore, CRD patients should be prioritized for booster vaccinations."

基金机构："National Science and Technology Major Project of China [2017ZX1 0202203-007, 2017ZX10202203-008, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; Science and Technology Bureau of Chongqing, China [cstc2022ycjh-bgzxm00519]; kuanren talents program of the second affiliated hospital of Chongqing medical University"

基金资助正文："This work is supported by the National Science and Technology Major Project of China (2017ZX1 0202203-007, 2017ZX10202203-008, 2018ZX10302206-003) and a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis. We also acknowledge the support of the National Natural Science Foundation of China (81772198) , the Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389) , the Science and Technology Bureau of Chongqing, China (cstc2022ycjh-bgzxm00519) , and supported by the kuanren talents program of the second affiliated hospital of Chongqing medical University."