Autophagy and apoptosis: regulatory factors of chondrocyte phenotype transition in osteoarthritis

作者全名："Liu, Zhibo; Wang, Ting; Sun, Xianding; Nie, Mao"

作者地址："[Liu, Zhibo; Wang, Ting; Sun, Xianding; Nie, Mao] Chongqing Med Univ, Ctr Joint Surg, Dept Orthoped Surg, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China"

通信作者："Sun, XD; Nie, M (通讯作者)，Chongqing Med Univ, Ctr Joint Surg, Dept Orthoped Surg, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China."

来源：HUMAN CELL

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001000904100001

JCR分区：Q3

影响因子：3.4

年份：2023

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期号：　

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文献类型：Review; Early Access

关键词：Osteoarthritis; Phenotype; Metabolism; Hypertrophic; Senescence

摘要："Osteoarthritis (OA) is the main pathogenic factor in diseases that cause joint deformities. As the main manifestation of the progress of OA, cartilage degradation has been closely associated with the degeneration of chondrocytes, which is induced by inflammatory factors and other trauma factors. Autophagy and apoptosis are the main mechanisms for cells to maintain homeostasis and play crucial roles in OA. Under the influence of external environmental factors (such as aging and injury), the metabolism of cells can be altered, which may affect the extent of autophagy and apoptosis. With the progression of OA, these changes can alter the cell phenotypes, and the cells of different phenotypes display distinct differences in morphology and function. In this review, we have summarized the alteration in cell metabolism, autophagy, and the extent of apoptosis during OA progression and its effects on the cell phenotypes to provide new ideas for further research on the mechanisms of phenotypic transition and therapeutic strategies so as to reverse the cell phenotypes."

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