Effect of surgical treatment on patients with stage T3 or T4 triple-negative breast cancer: a SEER-based retrospective observational study

作者全名："Hu, Jie; Dai, Changling; Zhang, Yang; Chen, Weijun; Sun, Lihua; Zhang, Xu; Duan, Minjie; Fu, Hao; Long, Teng; Kang, Wei; Yin, Chengliang; Liu, Xiaozhu; Yu, Jie"

作者地址："[Hu, Jie; Chen, Weijun; Sun, Lihua] Taizhou Univ, Taizhou Cent Hosp, Dept Tumor Radiotherapy, Affiliated Hosp, Taizhou, Peoples R China; [Dai, Changling] Taizhou Univ, Taizhou Cent Hosp, Dept Hematol, Affiliated Hosp, Taizhou, Peoples R China; [Zhang, Yang; Duan, Minjie] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Zhang, Xu] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou, Peoples R China; [Fu, Hao] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Long, Teng] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 2, Chongqing, Peoples R China; [Kang, Wei] Guangzhou Lab, Dept Math Phys & Interdisciplinary Studies, Guangzhou, Peoples R China; [Yin, Chengliang] Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China; [Liu, Xiaozhu] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Yu, Jie] Qingdao Univ, Dept Med Imaging, Affiliated Taian City Cent Hosp, Tai An, Peoples R China"

通信作者："Liu, XZ (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China.; Yu, J (通讯作者)，Qingdao Univ, Dept Med Imaging, Affiliated Taian City Cent Hosp, Tai An, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001002588400001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：triple-negative breast cancer; median survival; overall survival; surgical group; non-surgical group

摘要："BackgroundThe use of surgery is controversial in patients with stage T3 or T4 triple-negative breast cancer (TNBC). We aimed to explore the effect of surgical treatment on overall survival (OS) of these patients. MethodsA total of 2,041 patients were selected and divided into the surgical and non-surgical groups based on the Surveillance, Epidemiology, and End Results database from 2010 to 2018. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were applied to balance covariates between different groups. The OS of the two groups were assessed by Kaplan-Meier survival curves and Cox proportional hazards regression models. ResultsA total of 2,041 patients were included in the study. After PSM and IPTW, baseline characteristics of the matched variables were fully balanced. Kaplan-Meier survival curves showed that the median survival time and OS of TNBC patients with stage T3 or T4 in the surgical group were significantly improved compared with those in the non-surgical group. Multivariate Cox proportional hazards regression analysis showed that surgery was a protective factor for prognosis. ConclusionOur study found that surgery prolonged the median survival and improved OS compared with the non-surgical group of TNBC patients with stage T3 or T4."

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