The policy implemented by the government and the protection effect of PM2.5 decreasing on blood pressure in adolescents: From a quasi-experimental study

作者全名："Liang, Xiaohua; Liang, Fengchao; Liu, Fangchao; Ren, Yanling; Tong, Jishuang; Feng, Wei; Qu, Ping; Luo, Shunqing"

作者地址："[Liang, Xiaohua; Ren, Yanling; Tong, Jishuang; Feng, Wei; Qu, Ping; Luo, Shunqing] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Epidemiol & Biostat, Chongqing Key Lab Pediat,Minist Educ Key Lab Child, Chongqing, Peoples R China; [Liang, Fengchao] Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China; [Liu, Fangchao] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing, Peoples R China; [Liang, Xiaohua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Epidemiol & Biostat, Chongqing Key Lab Pediat,Minist Educ Key Lab Child, 136 2nd St,Yuzhong Dist, Chongqing, Peoples R China"

通信作者："Liang, XH (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Epidemiol & Biostat, Chongqing Key Lab Pediat,Minist Educ Key Lab Child, 136 2nd St,Yuzhong Dist, Chongqing, Peoples R China."

来源：JOURNAL OF GLOBAL HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001002765800001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background High particulate matter with an aerodynamic diameter of 2.5 mu m or less (PM2.5) exposure levels posed a great risk to human health, but the protection effects of environmental protection on car-diovascular disease have not been systematically evaluated. This study aims to illustrate the effect of the decreased concentration of PM2.5 on blood pressure level in adolescents after enacting the protection mea-sures of environment from a cohort study.Methods A quasi-experimental study including 2415 children from the Chongqing Children's Health Cohort, aged 7.32 +/- 0.60 years with normal blood pressure at baseline, with 53.94% males, were analysed. Both the generalised linear regression model (GLM) and Poisson regres-sion model were used to calculate the impact of the declining exposure level of PM2.5 on blood pressure and the incidence of prehypertension and hypertension.Results The annual mean PM2.5 concentration in 2014 and in 2019 were 65.01 +/- 6.46 mu gmes per cubic metre (mu g / m3), 42.08 +/- 2.04 mu g / m3 respectively, and the decreased PM2.5 concentration between 2014 and 2019 was 22.92 +/- 4.51 mu g / m3. The effect of decreased PM2.5 con-centration by 1 mu g / m3 on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and the difference of blood pressure (BP) indexes between 2014 and 2019 were all signifi-cant (P < 0.001). The absolute differences of SBP (-3.598 mmHg; 95% confidence interval (CI) =-4.47,-2.72 mmHg), DBP (-2.052 mmHg; 95% CI =-2.80,-1.31 mmHg) and MAP (-2.568 mmHg; 95% CI =-3.27,-1.87 mmHg) in the group with a decreased level of >= 25.56 mu g / m3were more significant than those in a decreased concentration of PM2.5 for <25.56 mu g / m3 (P < 0.001). And the incidence of prehypertension and hyper-tension for three occasions blood pressure diagnose was 2.21% (95% CI = 1.37%-3.05%, P = 0.001) in children with PM2.5 decreased level <= 25.56 mu g / m3 (50%), which was significant higher than its' counter-parts 0.89% (95% CI = 0.37%-1.42%, P = 0.001).Conclusions Our study found the etiological relationship between the declining PM2.5 concentration and the BP values and the incidence of prehypertension and hypertension in children and adolescents, sug-gesting continuous environmental protection measures in China have achieved remarkable health benefits."

基金机构：Major Health Project of Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0001]; Chongqing Medical University [W0088]; National key research and development project [2017YFC0211705]; Intelligent Medicine Project [ZHYX202109]; Basic Research Project of Key Laboratory of Ministry of Education of China [GBRP-202106]; Joint Medical Research Project of Chongqing Municipal Health Commission; Chongqing Science and Technology Bureau [2020MSXM062]; Natural Science Foundation of Youth Project [81502826]; Education Commission of Chongqing Municipality [KJQN201900443]

基金资助正文："This work was supported by the Major Health Project of Chongqing Science and Technology Bureau (No. CSTC2021jscx-gksb-N0001) , Program for Youth Innovation in Future Medicine from Chongqing Medical University (No.W0088) , National key research and development project (No.2017YFC0211705) , Intelligent Medicine Project (No. ZHYX202109) , the Basic Research Project of Key Laboratory of Ministry of Education of China in 2021 (GBRP-202106) , Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau (No.2020MSXM062) , the Natural Science Foundation of Youth Project (No.81502826) , the Education Commission of Chongqing Municipality (No.KJQN201900443) . The funders had no role in the whole study research process, including study design, the data collection and analysis, the decision to publish, or the preparation of the manuscript."