Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression

作者全名："Yang, Dan; Zhou, Haipeng; Pu, Juncai; Liu, Yiyun; Gui, Siwen; Wang, Dongfang; Tao, Xiangkun; Li, Zhuocan; Zhong, Xiaogang; Tao, Wei; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng"

作者地址："[Yang, Dan; Zhou, Haipeng; Pu, Juncai; Liu, Yiyun; Gui, Siwen; Wang, Dongfang; Tao, Xiangkun; Li, Zhuocan; Zhong, Xiaogang; Tao, Wei; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Pu, Juncai; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Xie, Peng] Jin Feng Lab, Chongqing 401329, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Jin Feng Lab, Chongqing 401329, Peoples R China."

来源：METABOLIC BRAIN DISEASE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001004051600001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Depression; Blood; Metabolomics; Pathway crosstalk analysis; Network analysis

摘要："Depression is a serious mental illness, but the molecular mechanisms of depression remain unclear. Previous research has reported metabolomic changes in the blood of patients with depression, while integrated analysis based on these altered metabolites was still lacking. The objective of this study was to integrate metabolomic changes to reveal the underlying molecular alternations of depression. We retrieved altered metabolites in the blood of patients with depression from the MENDA database. Pathway analysis was conducted to explore enriched pathways based on candidate metabolites. Pathway crosstalk analysis was performed to explore potential correlations of these enriched pathways, based on their shared candidate metabolites. Moreover, potential interactions of candidate metabolites with other biomolecules such as proteins were assessed by network analysis. A total of 854 differential metabolite entries were retrieved in peripheral blood of patients with depression, including 555 unique candidate metabolites. Pathway analysis identified 215 significantly enriched pathways, then pathway crosstalk analysis revealed that these pathways were clustered into four modules, including amino acid metabolism, nucleotide metabolism, energy metabolism and others. Additionally, eight molecular networks were identified in the molecular network analysis. The main functions of these networks involved amino acid metabolism, molecular transport, inflammatory responses and others. Based on integrated analysis, our study revealed pathway-based modules and molecular networks associated with depression. These results will contribute to the underlying knowledge of the molecular mechanisms in depression."

基金机构："Natural Science Foundation Project of China [81820108015, 82101596]; Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; institutional funds from the Chongqing Science and Technology Commission [cstc2022ycjh-bgzxm0033]"

基金资助正文：This work was supported by the Natural Science Foundation Project of China (Grant no. 81820108015 and 82101596); Young Elite Scientists Sponsorship Program by CAST (Grant no. 2021QNRC001); the institutional funds from the Chongqing Science and Technology Commission (Grant no. cstc2022ycjh-bgzxm0033).