"Evaluation of risk factors, treatment options, and prognostic-related factors in patients with benign ureteral strictures: An 8-year single-center experience"

作者全名："Ou, Yangjie; Zhang, Guoqing; Zhu, Xin; Yin, Hubing; Gou, Xin; Deng, Yuanzhong"

作者地址："[Ou, Yangjie; Zhang, Guoqing; Zhu, Xin; Yin, Hubing; Gou, Xin; Deng, Yuanzhong] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Deng, Yuanzhong] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Deng, YZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF UROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001004171600001

JCR分区：Q3

影响因子：1.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：benign ureteral strictures; endourological surgery; reconstructive surgical procedure; stricture characteristics

摘要："Objectives: To investigate the etiology, therapeutic effect, and prognosis-related factors of benign ureteral strictures.Methods: We analyzed the date of 142 patients with benign ureteral strictures from 2013 to 2021. Ninety-five patients received endourological treatment and 47 patients underwent reconstruction. Preoperative, intraoperative, and postoperative information were compared and analyzed. Symptomatic improvement and radiographic blockage alleviation defined therapeutic success.Results: Stone-related factors caused 85.2% of cases. The overall success rate of endourological treatment was 51.6% versus 95.7% of reconstruction (p < 0.01). However, endourological treatment was better in terms of postoperative hospital stay time, operation time, and intraoperative blood loss (p < 0.001). In endourological group, patients with stricture length = 2 cm, mild-to-moderate hydronephrosis, proximal or distal stricture had a higher success rate. Multivariate regression analysis showed that the surgical method was the only independent risk factor affecting success and recurrence. Reconstruction success rate was higher than endourological treatment (p = 0.001, OR 0.057, 95% CI (0.011-0.291)), and recurrence rate was also lower (p = 0.001, HR 0.074, 95% CI (0.016-0.338)). No obvious recurrence was seen in reconstruction, and the median recurrence time in endourological treatment was 51 months.Conclusions: Stone-related factors are an important cause of benign ureteral strictures. Reconstruction is the gold standard treatment due to its high success rate and low recurrence rate. Endourological therapy is also preferred as the initial treatment in proximal or distal ureter with length = 2 cm and mild-to-moderate hydronephrosis. Further close follow-up is required after treatment."

基金机构：　

基金资助正文：