Mg-CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration

作者全名："Wei, Ling; Du, Zhiyun; Zhang, Chenguang; Zhou, Yingying; Zhu, Fangyu; Chen, Yumin; Zhao, Han; Zhang, Fengyi; Dang, Pengrui; Wang, Yijun; Meng, Yanze; Heng, Boon Chin; Zhang, Hongcheng; Song, Jinlin; Liu, Wenwen; Cai, Qing; Deng, Xuliang"

作者地址："[Wei, Ling; Zhou, Yingying; Zhu, Fangyu; Chen, Yumin; Zhao, Han; Wang, Yijun; Meng, Yanze; Liu, Wenwen; Deng, Xuliang] Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China; [Du, Zhiyun; Cai, Qing] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China; [Zhang, Chenguang] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Peoples R China; [Zhang, Fengyi] Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Peoples R China; [Dang, Pengrui] China Med Univ Shenyang, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, VIP Dept, Shenyang 110002, Peoples R China; [Heng, Boon Chin] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China; [Zhang, Hongcheng] Foshan Southern China Inst New Mat, Foshan 528200, Peoples R China; [Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Liu, WW; Deng, XL (通讯作者)，Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China.; Cai, Q (通讯作者)，Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China."

来源：ADVANCED MATERIALS INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001005738300001

JCR分区：Q2

影响因子：4.3

年份：2023

卷号：10

期号：20

开始页：　

结束页：　

文献类型：Article

关键词：angiogenesis; bone regeneration; crosstalk; hydroxyapatite; osteogenesis-angiogenesis coupling

摘要："For bone defect repair, it is critical to utilize biomaterials with pro-angiogenic properties to enhance osteogenesis. Hydroxyapatite (HA)-based materials widely used in clinical applications have shown much potential for bone repair. However, their predominant calcium phosphate (CaP) composition and poor biodegradability limit their angiogenic potential and hence osteogenic efficiency of HA-based materials. Here, a magnesium ion-doped calcium silicate/HA composite microscaffold (Mg-CS/HA) is fabricated to enhance angiogenesis and osteogenic efficiency for bone repair. Incorporation of CS improved the biodegradability of the Mg-CS/HA microscaffold, which could simultaneously release Si and Mg bioactive ions during the early stage of implantation, synergistically enhancing angiogenesis and osteogenic efficiency. In co-culture systems, the synergistic effects of Si and Mg ions promote the ""osteogenesis-angiogenesis coupling effect."" In vivo, the Mg-CS/HA microscaffold could significantly promote reconstruction of the vascular network and bone regeneration. This study thus provides a new strategy for coordinated release of bioactive ions to achieve synergistic effects on vascularized bone regeneration by HA-based bone implant materials."

基金机构：National Key Research and Development Program of China [2018YFE0194400]; National Natural Science Foundation of China [U22A20314]

基金资助正文："Acknowledgements L.W. and Z.D. contributed equally to this work. This work was supported by the National Key Research and Development Program of China (2018YFE0194400), the National Natural Science Foundation of China (Grant No. U22A20314)."