Altered MANF and RYR2 concentrations associated with hypolipidemia in the serum of patients with schizophrenia
作者全名："Xu, Ke; Zheng, Peng; Zhao, Shuang; Feng, Jinzhou; Pu, Juncai; Wang, Jiubing; Zhao, Shuqian; Wang, Haiyang; Chen, Jianjun; Xie, Peng"
作者地址："[Xu, Ke; Zheng, Peng; Feng, Jinzhou; Pu, Juncai; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xu, Ke; Zheng, Peng; Pu, Juncai; Wang, Haiyang; Xie, Peng] Chongqing Med Univ, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Dept Pathophysiol, Chongqing, Peoples R China; [Wang, Jiubing] Chongqing Mental Hlth Ctr, Dept Clin Lab, Chongqing, Peoples R China; [Zhao, Shuqian] Chongqing Mental Hlth Ctr, Dept Clin Psychol, Chongqing, Peoples R China; [Wang, Haiyang] Chongqing Med Univ, Key Lab Psychoseomadsy, Stomatol Hosp, Chongqing, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"
通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."
来源：JOURNAL OF PSYCHIATRIC RESEARCH
ESI学科分类：PSYCHIATRY/PSYCHOLOGY
WOS号：WOS:001007293400001
JCR分区：Q1
影响因子：3.7
年份：2023
卷号：163
期号：
开始页：142
结束页：149
文献类型：Article
关键词：Schizophrenia; Serum lipids; MANF; RYR2; Biomarker
摘要："Schizophrenia (SCZ) is associated with abnormal serum lipid profiles, but their relationship is poorly understood. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an important regulator of lipid metabolism. Previous studies have shown its involvement in the pathogenesis of numerous neuropsychiatric disorders, while its role in SCZ is still unknown. Therefore, this study was conducted to examine serum MANF levels in patients with SCZ , to investigate the potential relationship between MANF, serum lipid levels , SCZ. The results showed that total cholesterol (TC) levels were significantly lower in 225 patients with SCZ than in 233 healthy controls (HCs). According to Ingenuity Pathway Analysis, hypolipidemia is associated with SCZ via MANF/ ryanodine receptor 2 (RYR2) pathway. This theory was supported by another sample set, which showed significantly lower MANF levels and higher RYR2 levels in the serum of 170 SCZ patients compared to 80 HCs. Moreover, MANF and RYR2 levels both were significantly correlated with the severity of psychotic symptoms and TC levels. In addition, a model consisting of MANF and RYR2 was found to be effective in distinguishing SCZ patients from HCs. These findings suggested that the MANF/RYR2 pathway might serve as a bridge between hypolipidemia and SCZ, and MANF and RYR2 held promise as biomarkers for SCZ."
基金机构：National Key R & D Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; Na- tional Natural Science Foundation of China [81820108015]
基金资助正文："Funding This study was supported by the National Key R & D Program of China (2017YFA0505700) , the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002) , and the Na- tional Natural Science Foundation of China (81820108015) ."
