Serum total bile acid levels assist in the prediction of acute intussusception with abdominal type Henoch-Schonlein purpura in children

作者全名："Yu, Sijie; Feng, Wei; Wang, Yi; Zhao, Maoyuan; Tu, Yuying; Guo, Zhenhua"

作者地址："[Yu, Sijie] Chongqing Med Univ, Childrens Hosp, Dept Nephrol, Chongqing, Peoples R China; [Yu, Sijie; Feng, Wei; Wang, Yi; Zhao, Maoyuan; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China; [Yu, Sijie; Feng, Wei; Wang, Yi; Zhao, Maoyuan; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders Chongqing, Chongqing, Peoples R China; [Yu, Sijie; Feng, Wei; Wang, Yi; Zhao, Maoyuan; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Yu, Sijie; Feng, Wei; Wang, Yi; Zhao, Maoyuan; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Feng, Wei; Wang, Yi; Zhao, Maoyuan; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, Dept Gen Surg, Chongqing, Peoples R China; [Tu, Yuying; Guo, Zhenhua] Chongqing Med Univ, Jiangxi Hosp, Childrens Hosp, Dept Gen Surg, Chongqing, Jiangxi, Peoples R China; [Tu, Yuying; Guo, Zhenhua] Jiangxi Maternal & Child Hlth Hosp, Jiangxi Childrens Med Ctr, Nanchang, Jiangxi, Peoples R China"

通信作者："Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders Chongqing, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Gen Surg, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Med Univ, Jiangxi Hosp, Childrens Hosp, Dept Gen Surg, Chongqing, Jiangxi, Peoples R China.; Guo, ZH (通讯作者)，Jiangxi Maternal & Child Hlth Hosp, Jiangxi Childrens Med Ctr, Nanchang, Jiangxi, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001007743000001

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：total bile acid (TBA); acute intussusception; Henoch-Schonlein purpura; children; prediction

摘要："BackgroundThe severe acute abdomen associated with Henoch-Schonlein purpura (HSP) is an acute intussusception (AI). There is no reliable specific marker for AI with abdominal-type HSP. The serum total bile acid (TBA) level is a new prognostic marker associated with the severity of intestinal inflammation. The purpose of this study was to identify the prognostic value of serum TBA levels for the diagnosis of AI in children with abdominal-type HSP. MethodsA retrospective study of 708 patients with abdominal-type HSP was conducted, with demographic data, clinical symptoms, hepatic function index, immune function markers, and clinical outcomes assessed. Patients were divided into two groups: HSP (613 patients) and HSP with AI (95 patients). The data were analysed using SPSS 22.0. ResultsOf the 708 patients, the serum TBA levels were higher in the HSP with AI group than in the HSP group (P < 0.05). Logistic regression analysis showed that vomiting (OR = 396.492, 95% CI = 14.93-10,529.67, P < 0.001), haematochezia (OR = 87.436, 95% CI = 5.944-1,286.214, P = 0.001), TBA (OR = 16.287, 95% CI = 4.83-54.922, P < 0.001), and D-dimer (OR = 5.987, 95% CI = 1.892-15.834, P = 0.003) were independent risk factors for abdominal-type HSP with AI. Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off serum TBA value (sensitivity = 91.58%, specificity = 84.67%, AUC = 93.6524%) was >3 mu mol/L for predicting AI in children with abdominal-type HSP. In this group of HSP patients with AI, a serum TBA level >= 6.98 mu mol/L was significantly associated with an increased incidence of operative treatment (51.85% vs. 75.61%, P = 0.0181), intestinal necrosis (9.26% vs. 29.27%, P = 0.0117), and length of hospital stay [15.76 +/- 5.31 vs. 10.98 +/- 2.83 (days), P < 0.0001]. ConclusionIn children with HSP and AI, the serum TBA level was significantly higher. A novel but promising haematological indicator, the serum TBA level, helps identify HSP with and without AI and predicts intestinal necrosis in HSP with AI."

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