Up-Conversion Luminescence System for Quantitative Detection of IL-6

作者全名："Chu, Zhengkang; Guo, Jiuchuan; Guo, Jinghong"

作者地址："[Chu, Zhengkang; Guo, Jiuchuan; Guo, Jinghong] Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, Chongqing 400016, Peoples R China"

通信作者："Guo, JH (通讯作者)，Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, Chongqing 400016, Peoples R China."

来源：IEEE TRANSACTIONS ON NANOBIOSCIENCE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001011414800001

JCR分区：Q1

影响因子：3.7

年份：2023

卷号：22

期号：2

开始页：203

结束页：211

文献类型：Article

关键词：Strips; Immune system; Sensitivity; Fluorescence; COVID-19; Bluetooth; Cameras; Up-conversion luminescence system; interleukin-6; up-conversion nanoparticles; quantitative detection; internet of medical things

摘要："Interleukin-6 (IL-6) is a very important cytokine and an early predictor of survival in febrile patients (eg, patients with COVID-19). With the outbreak of the COVID-19 in the world, the significance of medical detection of interleukin 6 has gradually become prominent. A method to point-of-care(POCT) diagnosis and monitoring of IL-6 levels in patients is urgently needed. In this work, an up-conversion luminescence system (ULS) based on upconverting nanoparticles (UCNs) for quantitative detection of IL-6 was designed. The ULS consists of Micro Controller Units (MCU), transmission device, laser, image acquisition module, Bluetooth module, etc. Through hardware system acquisition and image software algorithm processing, we obtain a limit of detection (LOD) of IL-6 at 1 ng/mL, and the quantitative range is from 1 to 200 ng/mL. The system is handheld and has great detection accuracy. The detection time is 10 minutes. In addition, the system can access mobile device terminals (smartphones, personal computers, etc.) or 5G cloud servers via Bluetooth and WIFI. Patients and family members can view medical data through mobile terminals, and the data stored in the 5G cloud server can be used for edge computing and big data analysis. It is suitable for the early diagnosis of infectious diseases such as COVID-19 and has good application prospects."

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