Magnetic nanoprobe-enabled lateral flow assays: recent advances

作者全名："Zhao, Ying; Sang, Jingwei; Fu, Yusheng; Guo, Jiuchuan; Guo, Jinhong"

作者地址："[Zhao, Ying] Sichuan Univ, West China Hosp, Inst Resp Hlth, Frontiers Sci Ctr Dis,Related Mol Network,Precis M, Chengdu, Peoples R China; [Sang, Jingwei; Fu, Yusheng; Guo, Jiuchuan] Univ Elect Sci & Technol China, Chengdu 611731, Peoples R China; [Guo, Jinhong] Shanghai Jiao Tong Univ, Sch Sensing Sci & Engn, Shanghai, Peoples R China; [Guo, Jinhong] Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Sang, JW (通讯作者)，Univ Elect Sci & Technol China, Chengdu 611731, Peoples R China."

来源：ANALYST

ESI学科分类：CHEMISTRY

WOS号：WOS:001016647900001

JCR分区：Q2

影响因子：3.6

年份：2023

卷号：148

期号：15

开始页：3418

结束页：3431

文献类型：Review

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摘要："In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in lateral flow immunoassays (LFIAs). Although the visual signal of magnetic nanoparticles is reduced during an inspection, it can be compensated for by magnetic induction, and detection results can be quantified by magnetic sensors. Sensors that use magnetic nanoparticles (MNPs) as markers can overcome the high background noise of complex samples. In this study, MNP signal detection strategies are described from the perspectives of magnetoresistance, magnetic flux, frequency mixing technology, and magnetic permeability, and the principles and development of each technology are introduced in detail. Typical applications of magnetic nanoparticle sensor technologies are introduced. By describing the advantages and limitations of different sensing strategies, we highlight the development and improvement directions of different sensing strategies. In general, the future development of magnetic nanoparticle sensor technologies will be toward intelligent, convenient, and mobile high-performance detection equipment."

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