Joint fluid interleukin-6 combined with the neutral polymorphonuclear leukocyte ratio (PMN%) as a diagnostic index for chronic periprosthesis infection after arthroplasty

作者全名："Su, Xudong; Zhu, Bo; Qin, Leilei; Yang, Jianye; Wei, Li; Xu, Zhenghao; Wei, Keyu; Wang, Jiayi; Chen, Li; Zhao, Chen; Chen, Cheng; Huang, Wei; Xiong, Yan; Hu, Ning"

作者地址："[Su, Xudong; Zhu, Bo; Qin, Leilei; Yang, Jianye; Wei, Li; Xu, Zhenghao; Wei, Keyu; Wang, Jiayi; Chen, Li; Zhao, Chen; Chen, Cheng; Huang, Wei; Hu, Ning] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China; [Su, Xudong; Zhu, Bo; Qin, Leilei; Yang, Jianye; Wei, Li; Xu, Zhenghao; Wei, Keyu; Wang, Jiayi; Chen, Li; Zhao, Chen; Chen, Cheng; Huang, Wei; Hu, Ning] Chongqing Med Univ, Lab Orthoped, Chongqing 400016, Peoples R China; [Xiong, Yan] Army Med Univ, Daping Hosp, Dept Orthoped, Chongqing, Peoples R China"

通信作者："Hu, N (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China.; Hu, N (通讯作者)，Chongqing Med Univ, Lab Orthoped, Chongqing 400016, Peoples R China.; Xiong, Y (通讯作者)，Army Med Univ, Daping Hosp, Dept Orthoped, Chongqing, Peoples R China."

来源：JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY

ESI学科分类：　

WOS号：WOS:001019999300001

JCR分区：Q1

影响因子：3

年份：2023

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Joint fluid; Interleukin 6; Neutral polymorphonuclear leukocytes (PMN%); Periprosthetic infection; Diagnosis

摘要："BackgroundThe diagnosis of periprosthetic joint infection (PJI) remains a challenge in clinical practice. Many novel serum and joint fluid biomarkers have important implications for the diagnosis of PJI. The presented study evaluated the value of joint fluid interleukin-6 (IL-6) combined with the neutral polymorphonuclear leukocyte (PMN%) ratio for chronic PJI diagnosis after arthroplasty.Materials and methodsSixty patients with chronic PJI or aseptic failure who underwent hip or knee revision from January 2018 to January 2020 in our department were included in this retrospective study. According to the 2013 MSIS diagnostic criteria, the 60 patients were divided into a PJI group and a non-PJI group (30 patients per group). We collected the joint fluid before surgery and determined the level of IL-6 and the PMN% by ELISA, and the differences between the two groups were compared. The diagnostic efficacy of joint fluid IL-6 combined with PMN% in chronic PJI was analyzed using a receiver operating characteristic curve (ROC curve).ResultsThe diagnosis of PJI using joint fluid IL-6 combined with PMN% presented an area under the curve of 0.983, which was more accurate than the areas under the curve for diagnosis using IL-6 and PMN% individually (0.901 and 0.914, respectively). The optimal threshold values for IL-6 and PMN% were 662.50 pg/ml and 51.09%, respectively. Their sensitivity and specificity were 96.67% and 93.33%, respectively. The accuracy of the diagnosis of PJI was 95.00%.ConclusionsJoint fluid IL-6 combined with PMN% can be used as an auxiliary method to detect chronic infection around the prosthesis after hip/knee arthroplasty."

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