Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Animal Model of Female Reproduc Diseases: A Meta-Analysis
作者全名："Zhou, Yuanyang; Li, Qu; You, Shuang; Jiang, Huanhuan; Jiang, Linying; He, Fan; Hu, Lina"
作者地址："[Zhou, Yuanyang; You, Shuang; Jiang, Huanhuan; Jiang, Linying] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Zhou, Yuanyang; Li, Qu] Jinjiang Matern Hosp, Dept Obstet & Gynaecol, 22 Huangshan Rd, Deyang, Sichuan, Peoples R China; [He, Fan; Hu, Lina] Chongqing Med Univ, Ctr Reprod Med, Obstet & Gynecol Dept, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [He, Fan; Hu, Lina] Minist Educ Peoples Republ China, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [He, Fan; Hu, Lina] Reprod & Stem Cell Therapy Res Ctr Chongqing, Chongqing, Peoples R China"
通信作者："He, F; Hu, LA (通讯作者)，Chongqing Med Univ, Ctr Reprod Med, Obstet & Gynecol Dept, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China.; He, F; Hu, LA (通讯作者)，Minist Educ Peoples Republ China, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China.; He, F; Hu, LA (通讯作者)，Reprod & Stem Cell Therapy Res Ctr Chongqing, Chongqing, Peoples R China."
来源：STEM CELL REVIEWS AND REPORTS
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001020343500001
JCR分区：Q2
影响因子：4.5
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：Mesenchymal Stem Cell-Derived Extracellular Vesicles; Exosomes; Female Reproductive Diseases; Premature Ovarian Insufficiency; Intrauterine Adhesion; Meta-Analysis
摘要："Background Female reproductive disorders, such as premature ovarian insufficiency (POI), intrauterine adhesion (IUA) or thin endometrium, and polycystic ovary syndrome (PCOS), are the main factors affecting fertility. Mesenchymal stem cells derived-extracellular vesicles (MSC-EVs) have gained traction as a new potential treatment and were widely studied in these diseases. However, their impact is still not fully clear. Methods A systematic search of PubMed, Web of Science, EMBASE, the Chinese National Knowledge of Infrastructure, and WanFang online databases was performed up to September 27(th), 2022, and the studies of MSC-EVs-based therapy on the animal models of female reproductive diseases were included. The primary outcomes was anti-Mullerian hormone (AMH) in POI and endometrial thickness in IUA, respectively. Results 28 studies (POI, N = 15; IUA, N = 13) were included. For POI, MSC-EVs improved AMH at 2 weeks (SMD 3.40, 95% CI 2.02 to 4.77) and 4 weeks (SMD 5.39, 95% CI 3.43 to 7.36) compared with placebo, and no difference was found when compared with MSCs in AMH (SMD -2.03, 95% CI -4.25 to 0.18). For IUA, MSC-EVs treatment could increase the endometrial thickness at 2 weeks (WMD 132.36, 95% CI 118.99 to 145.74), but no improvement was found at 4 weeks (WMD 166.18, 95% CI -21.44 to 353.79). The combination of MSC-EVs with hyaluronic acid or collagen had a better effect on the endometrial thickness (WMD 105.31, 95% CI 85.49 to 125.13) and glands (WMD 8.74, 95% CI 1.34 to 16.15) than MSC-EVs alone. The medium dose of EVs may allow for great benefits in both POI and IUA. Conclusions MSC-EVs treatment could improve the functional and structural outcomes in female reproductive disorders. the combination of MSC-EVs with HA or collagen may enhance the effect. These findings can accelerate the translation of MSC-EVs treatment to human clinical trials"
基金机构："Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University; Program for Youth Innovation in Future Medicine, Chongqing Medical University"
基金资助正文："This study was supported by Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University (to F. H.), and Program for Youth Innovation in Future Medicine, Chongqing Medical University (to F. H.)."
