The association between early fluid strategy and prognosis of acute respiratory distress syndrome: A post hoc study of CHARDS

作者全名："Chen, Ziying; Huang, Xu; Lu, Haining; Deng, Wang; Huang, Linna; Wu, Dawei; Wang, Daoxin; Zhan, Qingyuan; Wang, Chen"

作者地址："[Chen, Ziying; Zhan, Qingyuan; Wang, Chen] Peking Univ China, Japan Friendship Sch Clin Med, Beijing, Peoples R China; [Chen, Ziying; Huang, Xu; Huang, Linna; Zhan, Qingyuan; Wang, Chen] Natl Clin Res Ctr Resp Dis, China Japan Friendship Hosp, Ctr Resp Dis, Dept Pulm & Crit Care Med, Beijing, Peoples R China; [Lu, Haining; Wu, Dawei] Shandong Univ Qingdao, Dept Crit Care Med, Qilu Hosp, Qingdao, Peoples R China; [Deng, Wang; Wang, Daoxin] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Chen] Chinese Acad Med Sci, Peking Union Med Coll, Beijing, Peoples R China"

通信作者："Zhan, QY (通讯作者)，Peking Univ China, Japan Friendship Sch Clin Med, Beijing, Peoples R China.; Wu, DW (通讯作者)，Shandong Univ Qingdao, Dept Crit Care Med, Qilu Hosp, Qingdao, Peoples R China.; Wang, DX (通讯作者)，Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：PULMONARY CIRCULATION

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001020371200001

JCR分区：Q2

影响因子：2.2

年份：2023

卷号：13

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：acute respiratory distress syndrome; adult; fluid management

摘要："We aimed to assess general fluid management in China and evaluate the association between fluid balance and survival outcomes in acute respiratory distress syndrome (ARDS) patients. A retrospective, multicenter study including ARDS patients was conducted. We described the fluid management of ARDS patients in China. Furthermore, clinical characteristics and outcomes of patients subdivided by cumulative fluid balance were also analyzed. Multivariable logistic regression analysis was performed with hospital mortality as the outcome. From June 2016 to February 2018, 527 ARDS patients were included in our study. The mean cumulative fluid balance was 1669 (-1101 to 4351) mL in the first 7 day after intensive care unit (ICU) admission. Patients were divided into four groups based on cumulative fluid balance of the first 7 day after ICU admission: Group I (& LE;0 L), Group II (>0 L, & LE;3 L), Group III (>3 L, & LE;5 L), and Group IV (>5 L). Significantly lower hospital mortality was observed in patients with a lower cumulative fluid balance on day 7 of ICU admission (20.5% in Group I vs. 32.8% in Group II, 38.5% in Group III, and 50% in Group IV, p < 0.001). A lower fluid balance is associated with lower hospital mortality in patients with ARDS. However, a large-scale and well-designed randomized controlled trial is needed in the future."

基金机构：CAMS Innovation Fund for Medical Sciences; Beijing Municipal Science and Technology Project

基金资助正文：CAMS Innovation Fund for Medical Sciences and Beijing Municipal Science and Technology Project