Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study

作者全名："Wang, Jinkui; Li, Mujie; Guo, Peng; He, Dawei"

作者地址："[Wang, Jinkui; Li, Mujie; He, Dawei] Chongqing Med Univ, Dept Urol, Childrens Hosp, 2 ZhongShan Rd, Chongqing 400013, Peoples R China; [Wang, Jinkui; Li, Mujie; He, Dawei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, Chongqing, Peoples R China; [Guo, Peng] Chinese Acad Sci, IBMC, Hangzhou, Zhejiang, Peoples R China"

通信作者："He, DW (通讯作者)，Chongqing Med Univ, Dept Urol, Childrens Hosp, 2 ZhongShan Rd, Chongqing 400013, Peoples R China.; He, DW (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, Chongqing, Peoples R China."

来源：JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001020893300003

JCR分区：Q1

影响因子：2.8

年份：2023

卷号：18

期号：1

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结束页：　

文献类型：Article

关键词：Osteosarcoma; Chemotherapy; Survival; Challenge; SEER

摘要："BackgroundOsteosarcoma is the most prevalent primary malignant bone tumor. The primary treatment for osteosarcoma is a combination of chemotherapy and surgery. However, there has been no recent progress in the role of chemotherapy in improving the long-term survival of osteosarcoma patients. This study aims to analyze the factors that affect chemotherapy in patients with osteosarcoma and explore the challenges and survival benefits of chemotherapy.MethodsPatient data were downloaded from The Surveillance, Epidemiology, and End Results database. Univariable and multivariable logistic regressions were used to analyze the factors affecting patients receiving chemotherapy. Kaplan-Meier (K-M) curve was used to analyze the survival benefit of chemotherapy in patients with osteosarcoma. Finally, we used annual percentage change (APC) to evaluate the annual changes in chemotherapy treatment rates and trends in 5-year survival rates in osteosarcoma patients.ResultsA total of 2157 osteosarcoma patients were included, of which 1887 patients received chemotherapy. Factors affecting patients receiving chemotherapy included age, primary tumor site, tumor size, N stage, M stage, and surgery. The K-M curve showed that older patients could benefit significantly from chemotherapy. The APC results showed no significant change in the chemotherapy treatment rate and 5-year overall survival rate of osteosarcoma patients.ConclusionChemotherapy is an irreplaceable treatment for patients with osteosarcoma. However, in recent years, there has been no significant progress in chemotherapy for osteosarcoma, and the long-term survival of patients has not improved significantly. New chemotherapeutic drugs or drug delivery systems are urgently needed to improve the prognosis of patients with osteosarcoma."

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