Measurement of superoxide dismutase: clinical usefulness for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

作者全名："Zhang, Zhihuan; Huang, Wenhan; Ren, Feifeng; Luo, Lei; Zhou, Jun; Tang, Lin"

作者地址："[Zhang, Zhihuan; Huang, Wenhan; Ren, Feifeng; Luo, Lei; Zhou, Jun; Tang, Lin] Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Tang, L (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：ADVANCES IN RHEUMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001021093000001

JCR分区：Q3

影响因子：2

年份：2023

卷号：63

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：ANCA; Vasculitis; Superoxide dismutase; Oxidative stress

摘要："ObjectiveTo investigate the clinical usefulness of serum superoxide dismutase (SOD) measurement in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsIn this single-center retrospective study, demographic data, serum SOD levels, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), the Birmingham Vasculitis Activity Score (BVAS), ANCA, organ involvement, and outcomes were analyzed for 152 AAV patients hospitalized in the Second Affiliated Hospital of Chongqing Medical University. Meanwhile, the serum SOD levels of 150 healthy people were collected as the control group.ResultsCompared to the healthy control group, serum SOD levels of the AAV group were significantly lower (P < 0.001). SOD levels of AAV patients were negatively correlated to ESR, CRP, and BVAS (ESR rho = - 0.367, P < 0.001; CRP rho = - 0.590, P < 0.001; BVAS rho = - 0.488, P < 0.001). SOD levels for the MPO-ANCA group were significantly lower than the PR3-ANCA group (P = 0.045). SOD levels for the pulmonary involvement group and the renal involvement group were significantly lower than those for the non-pulmonary involvement group and the non-renal involvement group (P = 0.006; P < 0.001, respectively). SOD levels in the death group were significantly lower than the survival group (P = 0.001).ConclusionsIn AAV patients, low SOD levels might indicate disease associated oxidative stress. SOD levels in AAV patients were decreased with inflammation, suggesting that SOD levels could potentially be a surrogate marker for disease activity. SOD levels in AAV patients were closely related to ANCA serology, pulmonary involvement, and renal involvement, with low SOD levels an important indicator of a poor prognosis for AAV patients."

基金机构：National Natural Science Foundation of China [81771738]; Talents Program of Chongqing; CQMU Program for Youth Innovation in Future Medicine; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This work was supported by grant no. 81771738 from the National Natural Science Foundation of China, the Talents Program of Chongqing, the CQMU Program for Youth Innovation in Future Medicine and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."