Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey

作者全名："Sun, Xingyu; Zhang, Qiangsong; Kadier, Kaisaierjiang; Hu, Pengcheng; Liu, Xiaozhu; Liu, Jialing; Yan, Yulu; Sun, Chenyu; Yau, Vicky; Lowe, Scott; Meng, Muzi; Liu, Ziru; Zhou, Meirong"

作者地址："[Sun, Xingyu; Liu, Ziru; Zhou, Meirong] Cent South Univ, Xiangya Hosp 2, Dept Gen Surg, Changsha, Peoples R China; [Sun, Xingyu] Southwest Med Univ, Dept Gynecol, Affiliated Tradit Chinese Med Hosp, Luzhou, Sichuan, Peoples R China; [Zhang, Qiangsong] Fudan Univ, Emergency Dept, East China Hosp, Shanghai, Peoples R China; [Kadier, Kaisaierjiang] Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China; [Hu, Pengcheng] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing, Peoples R China; [Liu, Xiaozhu] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Liu, Jialing] Chongqing Med Univ, Dept PhaseClin Trial Ctr 1, Affiliated Hosp 2, Chongqing, Peoples R China; [Yan, Yulu] Southwest Med Univ, Clin Med Sch, Luzhou, Sichuan, Peoples R China; [Sun, Chenyu] Anhui Med Univ, Dept Gen Surg, Affiliated Hosp 2, Hefei, Peoples R China; [Sun, Chenyu] Anhui Med Univ, Dept Thyroid & Breast Surg, Affiliated Hosp 2, Hefei, Peoples R China; [Yau, Vicky] Columbia Univ, Div Oral & Maxillofacial Surg, Irving Med Ctr, New York, NY USA; [Lowe, Scott] Kansas City Univ, Coll Osteopath Med, Kansas City, MO USA; [Meng, Muzi] Amer Univ, UK Program Site, Caribbean Sch Med, Preston, England; [Meng, Muzi] Bronxcare Hlth Syst, Bronx, NY USA"

通信作者："Zhou, MR (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Gen Surg, Changsha, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001022032400001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：diabetes status; prediabetes; type 2 diabetes; obesity; breast cancer; NHANES

摘要："ObjectivesThe aim of this study was to investigate the association between diabetes status and the risk of breast cancer among adult Americans, exploring the impact of BMI, age, and race on this relationship. MethodsA cross-sectional analysis of 8,249 individuals from the National Health and Nutrition Examination Survey (NHANES) was conducted. Diabetes was categorized as type 2 diabetes and prediabetes, with both conditions diagnosed according to the ADA 2014 guidelines. The association between diabetes status and breast cancer risk was explored using multiple logistic regression analysis. ResultsPatients with diabetes had higher odds of breast cancer (OR: 1.51; 95% CI 1.00 to 2.28), Using the two-piecewise linear regression model, it was observed that there is a threshold effect in the risk of breast cancer occurrence at the age of 52 years. Specifically, the risk of breast cancer is relatively low before the age of 52 but increases significantly after this age. ConclusionsThis study identified a significant association between diabetes status and breast cancer risk among adult Americans. We also found a threshold effect in breast cancer occurrence at the age of 52. Age was significantly associated with breast cancer risk in both Non-Hispanic White and Non-Hispanic Black individuals. These findings underscore the importance of diabetes management, maintaining a healthy BMI, and age-related risk considerations in reducing breast cancer risk."

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