"Meal timing of dietary total antioxidant capacity and its association with all-cause, CVD and cancer mortality: the US national health and nutrition examination survey, 1999-2018"

作者全名："Wang, Peng; Jiang, Xuye; Tan, Qilong; Du, Shanshan; Shi, Dan"

作者地址："[Wang, Peng; Shi, Dan] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Wang, Peng; Du, Shanshan] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Fuzhou, Fujian, Peoples R China; [Jiang, Xuye] Univ Copenhagen, Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark; [Tan, Qilong] Zhejiang Univ, Sch Publ Hlth, Sch Med, Dept Epidemiol & Biostat, Hangzhou, Zhejiang, Peoples R China; [Shi, Dan] Chongqing Med Univ, Res Ctr Environm & Human Hlth, Sch Publ Hlth, Chongqing, Peoples R China; [Shi, Dan] Chongqing Med Univ, Sch Publ Hlth, Nutr Innovat Platform Sichuan & Chongqing, Chongqing, Peoples R China"

通信作者："Shi, D (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China.; Du, SS (通讯作者)，Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Fuzhou, Fujian, Peoples R China.; Shi, D (通讯作者)，Chongqing Med Univ, Res Ctr Environm & Human Hlth, Sch Publ Hlth, Chongqing, Peoples R China.; Shi, D (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Nutr Innovat Platform Sichuan & Chongqing, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001022445500002

JCR分区：Q1

影响因子：5.6

年份：2023

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：DAC; Mortality; Meal timing; NHANES

摘要："BackgroundThe association of the meal timing of dietary total antioxidant capacity (DAC) with mortality is unclear. We aimed to investigate the association between the meal timing of DAC and all-cause, cardiovascular disease (CVD), and cancer mortality in general adult populations.MethodsA total of 56,066 adults who participated in the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were recruited for this study. Dietary intake (quantity and timing) was evaluated by nonconsecutive 24-h dietary recalls. The main exposure variables were the DAC across three meals (total, breakfast, lunch, and dinner; without coffee) and the difference between dinner and breakfast DAC (& UDelta; = dinner-breakfast; without coffee). The outcomes were all-cause, CVD, and cancer mortality. The adjusted hazard ratios [aHRs] and 95% confidence intervals [CI] were imputed by Cox proportional hazards regression.ResultsAmong the 56,066 participants, there were 8566 deaths from any cause, including 2196 from CVD and 1984 from cancer causes. Compared to participants in the lowest quintiles of the total DAC, those in the highest quintiles had 34% and 27% decreased risks of all-cause and CVD mortality, respectively (all-cause mortality: aHRs 0.66 [95% CI 0.57-0.76]; CVD mortality: aHRs 0.73 [95% CI 0.57-0.94]). More importantly, participants in the highest quintiles of the dinner DAC, but not those in that of breakfast or lunch, had a 24% decrease in all-cause mortality (aHRs 0.76 [95% CI 0.67-0.87]) compared with those in the lowest quintiles. Inverse associations were further confirmed for & UDelta; DAC (aHRs 0.84 [95% CI 0.74-0.96]). Above associations did not change when including DAC from snacks or tea. Mediation analysis showed that the total associations of total, dinner or & UDelta; DACs with reduced all-cause mortality were 24%, 13% and 6%, respectively, mediated by serum CRP. Additionally, all-cause mortality was decreased by 7% in models replacing 10% breakfast DAC (aHRs 0.93 [95% CI 0.9-0.97]) with an equivalent proportion of dinner DAC. For cancer mortality, no statistical significance was detected in the adjusted models.ConclusionsThe findings emphasize the putative beneficial relationship of a diet rich in antioxidants and meal timing on serum CRP and all-cause mortality."

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