The relationship between inflammatory response markers and the prognosis of non-muscle invasive bladder cancer and the development of a nomogram model

作者全名："Yi, Xinping; Pi, Jiangchuan; Liu, Chuan; Xiong, Yongjiang; Liu, Jiaji; Fu, Wenyu; Wang, Lanxi; Zhao, Tao"

作者地址："[Yi, Xinping; Xiong, Yongjiang; Liu, Jiaji; Fu, Wenyu; Zhao, Tao] Chongqing Med Univ, Dept Urol, Yongchuan Hosp, Chongqing, Peoples R China; [Pi, Jiangchuan] Chengdu Second Peoples Hosp, Dept Urol, Chengdu, Peoples R China; [Liu, Chuan] Chongqing Med Univ, Dept Urol, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Lanxi] Chongqing Med Univ, Ophthalmol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Zhao, T (通讯作者)，Chongqing Med Univ, Dept Urol, Yongchuan Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001024991400001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：inflammatory factors; prognostic risk factors; tumor recurrence; Kaplan-Meier survival; intravesical instillation

摘要："PurposePatients with non-muscle invasive bladder cancer (NMIBC) have a high possibility of recurrence after surgery. We aimed to assess the factors associated with tumor recurrence and to construct a nomogram model that can contribute to personalized treatment plans of each patient. Methods496 patients with primary bladder cancer (BC) from 2 centers were retrospectively analyzed. Preoperative neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and traditional clinical parameters were collected, then using univariate and multivariate Cox regression analysis to find out the independent risk factors associated with tumor recurrence among them, and then these independent factors were incorporated into the nomogram model. The internal calibration curves and the external calibration curves were used to verify their usefulness. ResultsIn the training cohort, 150 patients (43.1%) experienced recurrence. After Cox regression analysis, the independent risk factors affecting recurrence-free survival (RFS) were tumor grade, immediate postoperative instillation therapy (IPPIT), NLR, and SII. These factors were used to construct a model to predict RFS 1, 2, 3, and 5 years of NMIBC patients after surgery. And then, we found that the constructed model outperforms the conventional model in terms of accuracy and predictability, the results were verified by statistical tests. ConclusionPreoperative inflammatory response markers have a predictive value for postoperative recurrence in patients with NMIBC. The constructed nomogram model can be helpful in guiding personalized clinical evaluation and subsequent treatment."

基金机构：Postgraduate Innovation Fund Project of Yongchuan Hospital of Chongqing Medical University [YJSCX202211]

基金资助正文：Funding This research was funded by the Postgraduate Innovation Fund Project of Yongchuan Hospital of Chongqing Medical University [grant numbers YJSCX202211].