Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies

作者全名："Wu, Yujia; Yu, Cong; Gao, Feng"

作者地址："[Wu, Yujia; Yu, Cong] Chongqing Med Univ, Stomatol Hosp Affiliated, Chongqing, Peoples R China; [Wu, Yujia; Yu, Cong] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Wu, Yujia; Yu, Cong] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Gao, Feng] Sixth Peoples Hosp Chongqing, Chongqing, Peoples R China"

通信作者："Gao, F (通讯作者)，Sixth Peoples Hosp Chongqing, Chongqing, Peoples R China."

来源：PERIOPERATIVE MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001029438900001

JCR分区：Q2

影响因子：2

年份：2023

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Postoperative cognitive dysfunction; Oral and maxillofacial malignancies; Risk factors; Anaesthesia; Elderly patients

摘要："We aimed to analyse postoperative cognitive dysfunction (POCD) incidence and risk factors in elderly adults who underwent surgery for oral malignancies. A total of 112 elderly patients (aged & GE; 55 years) were selected for expanded resection of oral malignancy and cervical lymphatic dissection at our institution from December 2020 to December 2021. Participants were cognitively evaluated using the neuropsychological test scale 1 day before and 7 days after surgery to determine whether they had developed POCD. Based on whether POCD occurred 7 days after surgery, patients were classified into the POCD and non-POCD groups. Logistic regression was applied to perioperative factors to analyse the risk factors for POCD onset. Seven days after surgery for oral malignancy, there were 37 (33.1%) POCD morbidities. Multiple factor logistic regression analysis revealed that venerable age (odds ratio [OR] = 1.269, 95% confidence interval [CI] 1.056-1.525, P < 0.05), low education levels (OR = 0.792, 95% CI 0.644-0.974, P < 0.05), hypertension (OR = 4.153, 95% CI 1.335-12.732, P < 0.05), dyssomnia (OR = 1.272, 95% CI 1.001-1.617, P < 0.05), prolonged anaesthesia (OR = 1.009, 95% CI 1.001-1.018, P < 0.05), and intraoperative hypotension (OR = 5.512, 95% CI 1.240-24.506, P < 0.05) increased the POCD risk in elderly patients who underwent surgery for oral malignancies. Venerable age, low knowledge reserve, hypertension, dyssomnia, prolonged anaesthesia, and intraoperative hypotension are independent risk factors for POCD in elderly patients with oral malignancies."

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