Circulating antibodies to Helicobacter pylori are associated with biomarkers of neurodegeneration in cognitively intact adults

作者全名："Wang, Ye-Ran; Liang, Chun-Rong; Heng, Tian; Zhang, Ting; Hu, Xiao-Tong; Long, Yan; Huang, Liang; Dong, Bo; Gao, Xia; Deng, Juan; Xu, Xia; Yao, Xiu-Qing"

作者地址："[Wang, Ye-Ran; Zhang, Ting; Hu, Xiao-Tong; Long, Yan; Huang, Liang; Dong, Bo; Gao, Xia; Deng, Juan; Xu, Xia] Third Mil Med Univ, Army Med Univ, Daping Hosp, Ctr Hlth Management, Chongqing 400042, Peoples R China; [Liang, Chun-Rong] Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Sleep & Psychol, Chongqing 400042, Peoples R China; [Heng, Tian; Yao, Xiu-Qing] Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil, Chongqing 400010, Peoples R China"

通信作者："Xu, X (通讯作者)，Third Mil Med Univ, Army Med Univ, Daping Hosp, Ctr Hlth Management, Chongqing 400042, Peoples R China.; Yao, XQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil, Chongqing 400010, Peoples R China."

来源：ASIAN JOURNAL OF PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001029941200001

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：86

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Helicobacter Pylori; Infection; Autoimmune; Antibodies to Helicobacter Pylori

摘要："Helicobacter pylori (H. pylori) infection confers risk for Alzheimer's Disease (AD), with the mechanisms unknown. Infections are linked to the etiology of AD partly through modulating the humoral immunity postinfection. This study found increased plasma levels of tTau and pTau181 in H. Pylori infected individuals with intact cognition. Plasma antibodies to H. pylori were positively associated with A & beta;40, A & beta;42, tTau, and pTau181, adjusting for age, sex, education level, BMI, ApoE & epsilon;4 genotype, hypertension, diabetes mellitus, and hypercholesteremia. This study presents novel insights into the relationship between H. pylori infection and AD from an autoimmune perspective."

基金机构："National Natural Science Foundation ofChina [81701046, 81971033]; Natural Science Foundation of Chongqing [cstc2020jcyj msxmX0204]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [kryc-lj-2105]"

基金资助正文："This study is supported by National Natural Science Foundation ofChina (No. 81701046 to WYR and No. 81971033 to YXQ) , Natural Science Foundation of Chongqing (No. cstc2020jcyj msxmX0204) , and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (Grant No. kryc-lj-2105) ."