Effect of massive cerebellar infarction on the outcomes of patients with acute basilar artery occlusion during hospitalization after endovascular treatment: A retrospective study

作者全名："Wu, Chuyue; Wang, Jing; Zhang, Lina; Yan, Fei; Yang, Zhenjie; He, Lei; Guo, Jing"

作者地址："[Wu, Chuyue; Wang, Jing; Zhang, Lina; He, Lei; Guo, Jing] Chongqing Univ, Gorges Hosp 3, Dept Neurol, Chongqing, Peoples R China; [Wu, Chuyue; Wang, Jing; Zhang, Lina; Yan, Fei; Guo, Jing] Chongqing Univ, Sch Med, Chongqing, Peoples R China; [Wu, Chuyue; Wang, Jing; Zhang, Lina; Yan, Fei; Guo, Jing] Chongqing Univ, Gorges Hosp 3, Chongqing Municipal Clin Res Ctr Geriatr Dis, Chongqing, Peoples R China; [Wu, Chuyue] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China; [Wang, Jing; Guo, Jing] Chongqing Med Univ, Yongchuan Hosp, Chongqing, Peoples R China; [Yang, Zhenjie] Chongqing Univ, Gorges Hosp 3, Dept Radiol, Chongqing, Peoples R China; [Guo, Jing] Chongqing Univ, Gorges Hosp 3, Dept Neurol, 165 Xincheng Rd, Chongqing 404100, Peoples R China"

通信作者："Guo, J (通讯作者)，Chongqing Univ, Gorges Hosp 3, Dept Neurol, 165 Xincheng Rd, Chongqing 404100, Peoples R China."

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001034383100005

JCR分区：Q2

影响因子：1.3

年份：2023

卷号：102

期号：29

开始页：　

结束页：　

文献类型：Article

关键词：acute basilar artery occlusion; endovascular treatment; massive cerebellar infarction; outcome

摘要："Acute basilar artery occlusion (ABAO) after endovascular treatment (EVT) is often associated with a poor prognosis, particularly in patients with cerebellar infarction who may develop malignant cerebellar edema. The present study aimed to investigate how massive cerebellar infarction (MCI) affects hospitalization outcomes in ABVO patients who undergo EVT. We conducted a retrospective study of ABVO patients who underwent EVT at our hospital between September 2017 and September 2022. MCI was diagnosed using imaging techniques, and various prognostic scores were assessed during hospitalization to examine the relationship between MCI and these outcomes. We identified 42 ABAO patients, of whom 22 (52.4%) had MCI. Patients with MCI had a higher modified Rankin Scale (mRS) score at discharge compared to those without MCI (4.36 & PLUSMN; 1.14 vs 3.05 & PLUSMN; 1.85, P = .042, odds ratio [OR] (95% confidence interval [CI]) = 1.093 (0.083, 2.103)), and a lower Glasgow Coma Scale score (6.59 & PLUSMN; 4.0 vs 10.10 & PLUSMN; 5.07, P = .036, OR (95% CI) = -3.444 (-6.518, -0.369)). MCI was identified as an independent risk factor for an extremely poor prognosis (mRS & GE; 5) at discharge (P = .036, OR (95% CI) = 15.531 (1.603, 313.026)) and for no improvement in mRS score compared to onset (P = .013, OR (95% CI) = 0.025 (0.001, 0.274)). Additionally, an extremely poor prognosis was independently associated with stent implantation, EVT duration, and body mass index, while mRS score improvement was correlated with EVT duration and pulmonary infection. MCI in ABAO patients is a significant independent risk factor for a poor prognosis at discharge and no improvement in function score compared to onset. Early diagnosis and intervention are necessary to improve outcomes, particularly in high-risk populations."

基金机构："Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0017, 2022NSCQ-BHX5277]; National Natural Science Foundation of China [12102072]; Technology Innovation and Application Demonstration Foundation of Chongqing Science and Technology Bureau [cstc2018jscx.msybX0128]"

基金资助正文："This work was supported by Chongqing Natural Science Foundation, General Program (No. cstc2020jcyj-msxmX0017), Chongqing Natural Science Foundation (No. 2022NSCQ-BHX5277), National Natural Science Foundation of China (No.12102072), and Technology Innovation and Application Demonstration Foundation of Chongqing Science and Technology Bureau (No. cstc2018jscx.msybX0128)"