"Nomograms for predicting overall survival in colorectal cancer patients with metastasis to the liver, lung, bone, and brain"

作者全名："Wang, Hongmei; Shan, Xuefeng; Zhang, Min; Qian, Kun; Shen, Zhengze; Zhou, Weiying"

作者地址："[Wang, Hongmei] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, Chongqing 400016, Peoples R China; [Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing 400016, Peoples R China; [Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing 400016, Peoples R China; [Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China; [Shan, Xuefeng] Chongqing Med Univ, Dept Pharm, Bishan Hosp, Chongqing 402760, Peoples R China; [Zhang, Min] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing 400016, Peoples R China; [Qian, Kun] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing 400016, Peoples R China; [Shen, Zhengze] Chongqing Med Univ, Yongchuan Hosp, Dept Pharm, Chongqing 402160, Peoples R China"

通信作者："Zhou, WY (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing 400016, Peoples R China.; Zhou, WY (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing 400016, Peoples R China.; Zhou, WY (通讯作者)，Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China.; Shen, ZZ (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Pharm, Chongqing 402160, Peoples R China."

来源：CANCER CAUSES & CONTROL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001034520600001

JCR分区：Q2

影响因子：2.2

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：Colorectal cancer; Metastases; Survival; SEER; Nomogram

摘要："BackgroundThe aim of this study was to identify the heterogeneous and homogeneous prognostic factors associated with distant metastasis to the liver, lung, bone, and brain in colorectal cancer (CRC) patients and then construct nomograms to predict the prognosis.MethodsCRC patients registered in the surveillance, epidemiology, and end results database between 2010 and 2017 were included. A Cox regression model was used to analyse homogeneous and heterogeneous prognostic factors, and Kaplan-Meier analysis was performed to estimate overall survival (OS). Predictive nomograms were constructed, and their performance was evaluated with C-indexes, calibration curves and the area under the receiver operating characteristic (ROC) curve (AUC).ResultsA total of 37,641 patients with distant metastasis to the liver, lung, bone, and brain were included. The median survival times of patients with liver metastasis, lung metastasis, bone metastasis, and brain metastasis were 12.00 months (95% CI 11.73-12.27 months), 10.00 months (95% CI 9.60-10.41 months), 5.00 months (95% CI 4.52-5.48 months), and 3.00 months (95% CI 2.28-3.72 months), respectively. An older age, higher N stage, elevated carcinoembryonic antigen level, no surgery at the primary site and no/unknown treatment with chemotherapy were identified as homogeneous prognostic factors for the four types of metastases. The calibration curves, C-indexes and AUCs exhibited good performance for predicting the OS of patients with distant metastases to the liver, lung, bone, and brain.ConclusionsCRC patients with distant metastasis to the liver, lung, bone, and brain exhibited homogeneous and heterogeneous prognostic factors, all of which were associated with shorter survival. The nomograms showed good accuracy and may be used as tools for clinicians to predict the prognosis of CRC patients with distant metastasis."

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