Real-World Data in Pharmacovigilance Database Provides a New Perspective for Understanding the Risk of Clostridium difficile Infection Associated with Antibacterial Drug Exposure

作者全名："Li, Dongxuan; Song, Yi; Bai, Zhanfeng; Xi, Xin; Liu, Feng; Zhang, Yang; Qin, Chunmeng; Du, Dan; Du, Qian; Liu, Songqing"

作者地址："[Li, Dongxuan; Song, Yi; Bai, Zhanfeng; Xi, Xin; Qin, Chunmeng; Du, Dan; Du, Qian; Liu, Songqing] Chongqing Med Univ, Affiliated Hosp 3, Dept Pharm, Chongqing 401120, Peoples R China; [Li, Dongxuan; Qin, Chunmeng] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Liu, Feng; Zhang, Yang] Chongqing Med Univ, Affiliated Hosp 3, Ctr Med Informat & Stat, Chongqing 401120, Peoples R China; [Du, Qian] Chongqing Med Univ, Med Data Sci Acad, Chongqing 400016, Peoples R China"

通信作者："Du, Q; Liu, SQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Pharm, Chongqing 401120, Peoples R China.; Du, Q (通讯作者)，Chongqing Med Univ, Med Data Sci Acad, Chongqing 400016, Peoples R China."

来源：ANTIBIOTICS-BASEL

ESI学科分类：　

WOS号：WOS:001034748400001

JCR分区：Q1

影响因子：4.3

年份：2023

卷号：12

期号：7

开始页：　

结束页：　

文献类型：Article

关键词：Clostridium difficile infection; antibacterial drug; FDA Adverse Event Reporting System; pharmacovigilance; disproportionality analysis; adverse reaction

摘要："Antibacterial drug exposure (ADE) is a well-known potential risk factor for Clostridium difficile infection (CDI), but it remains controversial which certain antibacterial drugs are associated with the highest risk of CDI occurrence. To summarize CDI risk associated with ADE, we reviewed the CDI reports related to ADE in the FDA Adverse Event Reporting System database and conducted disproportionality analysis to detect adverse reaction (ADR) signals of CDI for antibacterial drugs. A total of 8063 CDI reports associated with ADE were identified, which involved 73 antibacterial drugs. Metronidazole was the drug with the greatest number of reports, followed by vancomycin, ciprofloxacin, clindamycin and amoxicillin. In disproportionality analysis, metronidazole had the highest positive ADR signal strength, followed by vancomycin, cefpodoxime, ertapenem and clindamycin. Among the 73 antibacterial drugs, 58 showed at least one positive ADR signal, and ceftriaxone was the drug with the highest total number of positive signals. Our study provided a real-world overview of CDI risk for AED from a pharmacovigilance perspective and showed risk characteristics for different antibacterial drugs by integrating its positive-negative signal distribution. Meanwhile, our study showed that the CDI risk of metronidazole and vancomycin may be underestimated, and it deserves further attention and investigation."

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