"The Mediation and Moderation Effect Association among Physical Activity, Body-Fat Percentage, Blood Pressure, and Serum Lipids among Chinese Adults: Findings from the China Health and Nutrition Surveys in 2015"

作者全名："Zou, Qinpei; Su, Chang; Du, Wenwen; Ouyang, Yifei; Wang, Huijun; Zhang, Bing; Luo, Shuquan; Tan, Tao; Chen, Yaokai; Zhong, Xiaoni; Zhang, Huadong"

作者地址："[Zou, Qinpei; Luo, Shuquan; Zhang, Huadong] Chongqing Ctr Dis Control & Prevent, Chongqing 400042, Peoples R China; [Zou, Qinpei; Zhong, Xiaoni] Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Zou, Qinpei; Chen, Yaokai] Chongqing Publ Hlth Med Ctr, Dept Infect Dis, Chongqing 400036, Peoples R China; [Su, Chang; Du, Wenwen; Ouyang, Yifei; Wang, Huijun; Zhang, Bing] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China; [Tan, Tao] Chongqing Hlth Stat Informat Ctr, Chongqing 401120, Peoples R China"

通信作者："Zhang, HD (通讯作者)，Chongqing Ctr Dis Control & Prevent, Chongqing 400042, Peoples R China.; Zhong, XN (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing 400016, Peoples R China."

来源：NUTRIENTS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001036678800001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：15

期号：14

开始页：　

结束页：　

文献类型：Article

关键词：body-fat percentage; blood pressure; mediation effect; moderation effect; physical activity; serum lipids

摘要："Physical activity (PA) is of benefit and particularly important for cardiovascular disease risk factors as being sedentary becomes a lifestyle habit. Research into Chinese complex association among physical activity, body-fat percentage (BF%), blood pressure, and serum lipids is limited. The present study is based on an observational study among adults (>18 years old) residing in fifteen provinces in China. Data of 10,148 adult participants in the 2015 China Health and Nutrition Survey (CHNS) were analyzed. The simple mediation effect models with covariates were utilized to assess the association among PA and blood pressure or serum lipids, and BF% was played as a mediator. The serial multiple-mediator models with covariates were constructed to the further analysis of the relationship between PA and blood pressure, and BF% was the mediator 1 and blood lipids were the mediator 2. Based on the above hypothesis, the moderated mediation models with covariates were used to analyze the association among PA, BF%, and blood pressure; in addition, BF% was used as the mediator and blood lipids played as the moderator. In the simple mediation models, the model with a dependent variable was high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C); BF% was played as the partly mediation effect and the proportion of contribution was 0.23 and 0.25, respectively. In the serial multiple-mediator models, blood lipids, as the second mediator, played the mediation effect; however, the effect was smaller than the BF%. In the moderated mediation model, blood lipids had the moderation effect as the moderator variable. HDL-C played a moderating role in the latter pathway of the ""PA & RARR;BF%& RARR;SBP/DBP"" mediation model, and LDL-C/TC played a moderating role in the direct effect of the ""PA & RARR;BF%& RARR;DBP"". In conclusion, BF% played a mediating role in the relationship between PA and blood pressure. HDL-C, LDL-C, and TC were more likely to act as moderating variables in the mediation model ""PA & RARR;BF%& RARR;SBP/DBP"". PA could directly and indirectly benefit to control the CVD risk factors simultaneously."

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