Dual Photo-Enhanced Interpenetrating Network Hydrogel with Biophysical and Biochemical Signals for Infected Bone Defect Healing

作者全名："Jian, Guangyu; Li, Dize; Ying, Qiwei; Chen, Xu; Zhai, Qiming; Wang, Si; Mei, Li; Cannon, Richard D.; Ji, Ping; Liu, Wenzhao; Wang, Huanan; Chen, Tao"

作者地址："[Jian, Guangyu; Li, Dize; Chen, Xu; Zhai, Qiming; Wang, Si; Ji, Ping; Liu, Wenzhao; Chen, Tao] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Ying, Qiwei; Wang, Huanan] Dalian Univ Technol, Sch Bioengn, Key State Lab Fine Chem, Dalian 116023, Peoples R China; [Mei, Li; Cannon, Richard D.] Univ Otago, Sir John Walsh Res Inst Fac Dent, Dept Oral Sci, Dunedin 9054, New Zealand"

通信作者："Liu, WZ; Chen, T (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China.; Wang, HA (通讯作者)，Dalian Univ Technol, Sch Bioengn, Key State Lab Fine Chem, Dalian 116023, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001037290000001

JCR分区：Q1

影响因子：10

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：antibacterial materials; bioactive ions; hybrid hydrogels; immunomodulation; spatiotemporal regulation

摘要："The healing of infected bone defects (IBD) is a complex physiological process involving a series of spatially and temporally overlapping events, including pathogen clearance, immunological modulation, vascularization, and osteogenesis. Based on the theory that bone healing is regulated by both biochemical and biophysical signals, in this study, a copper doped bioglass (CuBGs)/methacryloyl-modified gelatin nanoparticle (MA-GNPs)/methacrylated silk fibroin (SilMA) hybrid hydrogel is developed to promote IBD healing. This hybrid hydrogel demonstrates a dual-photocrosslinked interpenetrating network mechanism, wherein the photocrosslinked SilMA as the main network ensures structural integrity, and the photocrosslinked MA-GNPs colloidal network increases strength and dissipates loading forces. In an IBD model, the hydrogel exhibits excellent biophysical characteristics, such as adhesion, adaptation to irregular defect shapes, and in situ physical reinforcement. At the same time, by sequentially releasing bioactive ions such as Cu2+, Ca2+, and Si2+ ions from CuBGs on demand, the hydrogel spatiotemporally coordinates antibacterial, immunomodulatory and bone remodeling events, efficiently removing infection and accelerating bone repair without the use of antibiotics or exogenous recombinant proteins. Therefore, the hybrid hydrogel can be used as a simple and effective method for the treatment of IBD."

基金机构："National Natural Science Foundation of China [32071362, 82201075, 82201059]; Key International (Regional) Joint Research Program - National Natural Science Foundation of China [82220108019]; China Postdoctoral Science Foundation [2022TQ0395]; Science Fund for Distinguished Young Scholars of Chongqing [CSTB2022NSCQ-JQX0012]"

基金资助正文："& nbsp;G.J. and D.L. contributed equally to this work. This work was supported by grants from the National Natural Science Foundation of China (Nos. 32071362, 82201075, and 82201059), Key International (Regional) Joint Research Program funded by National Natural Science Foundation of China (No. 82220108019), the China Postdoctoral Science Foundation (No. 2022TQ0395), and the Science Fund for Distinguished Young Scholars of Chongqing (No. CSTB2022NSCQ-JQX0012)."