The effect of antibiotic prophylaxis on the incidence of surgical site infection after laparoscopic appendectomy for chronic appendicitis

作者全名："Dai, Li; Jin, Xiangren; Xie, Haitao; He, Tong; Cheng, Honggang; Zhu, Yinwu; Wang, Liuxing; Huang, Fu; Liang, Baichuang; Gou, Xin; Wang, Qian; Wang, Haibin"

作者地址："[Dai, Li; Jin, Xiangren; Xie, Haitao; He, Tong; Wang, Liuxing; Huang, Fu; Liang, Baichuang; Wang, Qian; Wang, Haibin] Guizhou Med Univ, Affiliated Hosp, Guiyang 550001, Guizhou, Peoples R China; [Cheng, Honggang; Zhu, Yinwu; Gou, Xin] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Wang, HB (通讯作者)，Guizhou Med Univ, Affiliated Hosp, Guiyang 550001, Guizhou, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001042236300001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：Antibiotic prophylaxis; Chronic appendicitis; Laparoscopic appendectomy; Surgical site infection

摘要："Background: The guidelinesthat specify whether antibiotic prophylaxis should be administered before laparoscopic clean-contaminated wound to prevent postoperative surgical site infection (SSI) need to be improved. Studies have shown that elective laparoscopic cholecystectomy with clean-contaminated wound does not require antibiotic prophylaxis. However, there are no studies on the effect of antibiotic prophylaxis on SSI after laparoscopic appendectomy for chronic appendicitis (LCA), which is a clean-contaminated wound.Methods: We conducted a single-center, double-blind, randomized controlled clinical trial. A total of 106 effective patients were randomly divided into the antibiotic group and saline group. Cefuroxime or clindamycin was administered intravenously in the antibiotic group (n = 52). Saline (0.9%) was administered intravenously in the saline group (n = 54). Interventions were administered as a single dose 30 min before surgery.Results: Among the 106 effective patients (median age, 37 years old [IQR, 25-45]; females, 77 [72.6%]), there were 6 cases (5.70%) of SSI: 3 cases (5.56%) in the saline group and 3 cases (5.70%) in the antibiotic group (OR = 1.00, [95% CI (0.20-5.4)], P = 0.96). There were no significant differences in the clinical outcomes of anal exhaust time, postoperative complications, and the symptom of primary abdominal pain between the two groups.Conclusion: For patients with chronic appendicitis undergoing laparoscopic appendectomy, preoperative intravenous antibiotic prophylaxis did not reduce the risk of SSI within 30 days of the surgery compared to the saline group.Trial registration: Registration number of China Clinical Trials Registration Center: ChiCTR2100048336."

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