Cerebellar and cerebral white matter changes in Parkinson's disease with resting tremor

作者全名："Zhong, Yuke; Liu, Hang; Liu, Guohui; Liang, Yi; Dai, Chengcheng; Zhao, Lili; Lai, Hongyu; Mo, Lijuan; Tan, Changhong; Deng, Fen; Liu, Xi; Chen, Lifen"

作者地址："[Zhong, Yuke; Liu, Hang; Liu, Guohui; Liang, Yi; Dai, Chengcheng; Zhao, Lili; Lai, Hongyu; Mo, Lijuan; Tan, Changhong; Deng, Fen; Liu, Xi; Chen, Lifen] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Liu, X; Chen, LF (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：NEURORADIOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001043636400001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Parkinson's disease; Resting tremor; Diffusion tensor imaging; Cerebellum; White matter

摘要："PurposeCerebellum modulates the amplitude of resting tremor in Parkinson's disease (PD) via cerebello-thalamo-cortical (CTC) circuit. Tremor-related white matter alterations have been identified in PD patients by pathological studies, but in vivo evidence is limited; the influence of such cerebellar white matter alterations on tremor-related brain network, including CTC circuit, is also unclear. In this study, we investigated the cerebral and cerebellar white matter alterations in PD patients with resting tremor using diffusion tensor imaging (DTI).MethodsIn this study, 30 PD patients with resting tremor (PDWR), 26 PD patients without resting tremor (PDNR), and 30 healthy controls (HCs) from the Parkinson's Progression Markers Initiative (PPMI) cohort were included. Tract-based spatial statistics (TBSS) and region of interest-based analyses were conducted to determine white matter difference. Correlation analysis between DTI measures and clinical characteristics was also performed.ResultsIn the whole brain, TBSS and region of interest-based analyses identified higher fractional anisotropy (FA) value, lower mean diffusivity (MD) value, and lower radial diffusivity (RD) in multiple fibers. In the cerebellum, TBSS analysis revealed significantly higher FA value, decreased RD value as well as MD value in multiple cerebellar tracts including the inferior cerebellar peduncle (ICP) and middle cerebellar peduncle (MCP) when comparing the PDWR with HC, and higher FA value in the MCP when compared with PDNR.ConclusionWe identified better white matter integrity in the cerebrum and cerebellum in PDWR indicating a potential association between the cerebral and cerebellar white matter and resting tremor in PD."

基金机构：National Natural Science Foundation of China [82001367]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0180]; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University; Graduate Students Science Innovation Project of Chongqing [CYS22349]

基金资助正文："This study is supported by National Natural Science Foundation of China (grant number: 82001367, receiver: Xi Liu), Natural Science Foundation of Chongqing (grant number: cstc2021jcyj-msxmX0180, receiver: Xi Liu), Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University (receiver: Xi Liu), and Graduate Students Science Innovation Project of Chongqing (grant number: CYS22349, receiver: Yuke Zhong)."