"Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders"

作者全名："Long, Yicheng; Li, Xuemei; Cao, Hengyi; Zhang, Manqi; Lu, Bing; Huang, Yang; Liu, Mengqi; Xu, Ming; Liu, Zhening; Yan, Chaogan; Sui, Jing; Ouyang, Xuan; Zhou, Xinyu"

作者地址："[Long, Yicheng; Liu, Zhening; Ouyang, Xuan] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Long, Yicheng; Liu, Zhening; Ouyang, Xuan] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China; [Li, Xuemei; Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Cao, Hengyi] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA; [Cao, Hengyi] Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA; [Zhang, Manqi] South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Peoples R China; [Lu, Bing; Yan, Chaogan] Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China; [Lu, Bing; Xu, Ming; Yan, Chaogan] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China; [Huang, Yang; Liu, Mengqi] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Xu, Ming] Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China; [Xu, Ming] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China; [Sui, Jing] Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China"

通信作者："Ouyang, X (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.; Ouyang, X (通讯作者)，Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.; Sui, J (通讯作者)，Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China."

来源：PSYCHOLOGICAL MEDICINE

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001044055700001

JCR分区：Q1

影响因子：5.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Aging; brain network; connectome; functional connectivity; major depressive disorder

摘要："BackgroundThe age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis. MethodsThe analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12-17 years old; 411 early-middle adults, 18-54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively. ResultsWe found shared FC reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Furthermore, adolescent patients uniquely exhibited increased sensorimotor-subcortical FC; early-middle adult patients uniquely exhibited decreased visual-subcortical FC; and late adult patients uniquely exhibited wide FC reductions within the subcortical, default-mode, cingulo-opercular, and attention networks. Analysis of covariance models using the whole pooled sample further revealed: (1) significant main effects of age group on FCs within most brain networks, suggesting that they are decreased with aging; and (2) a significant age group x MDD diagnosis interaction on FC within the default-mode network, which may be reflective of an accelerated aging-related decline in default-mode FCs. ConclusionsTo summarize, these findings may deepen our understanding of the age-related biological and clinical heterogeneity in MDD."

基金机构："STI2030-Major Projects [2022ZD0212900]; National Natural Science Foundation of China [82271565, 82201692, 82071506]; Natural Science Foundation of Hunan Province, China [2021JJ40851]"

基金资助正文："Acknowledgements This work was supported by the STI2030-Major Projects (2022ZD0212900 to XZ), the National Natural Science Foundation of China (82271565 to XZ, 82201692 to YL, 82071506 to ZL), and the Natural Science Foundation of Hunan Province, China (2021JJ40851 to YL). The data of this study were partly provided by the members of the REST-meta-MDD Consortium."