Clinical Features and a Prediction Nomogram for Prognosis in Children with Escherichia coli Meningitis

作者全名："Zhang, Lingyu; Li, Wenjie; Peng, Xiaoling; Jiang, Li; Hu, Yue"

作者地址："[Zhang, Lingyu; Li, Wenjie; Jiang, Li; Hu, Yue] Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Zhang, Lingyu; Li, Wenjie; Jiang, Li; Hu, Yue] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zhang, Lingyu; Li, Wenjie; Jiang, Li; Hu, Yue] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Zhang, Lingyu; Li, Wenjie; Jiang, Li; Hu, Yue] China Int Sci & Technol Cooperat base Child Dev &, Chongqing, Peoples R China; [Zhang, Lingyu; Li, Wenjie; Jiang, Li; Hu, Yue] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Peng, Xiaoling] BNU HKBU United Int Coll, Guangdong Prov Key Lab Interdisciplinary Res & App, Zhuhai, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：JOURNAL OF CHILD NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001047475100001

JCR分区：Q2

影响因子：2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：bacterial meningitis; Escherichia coli; poor prognosis; prediction model; treatment

摘要："Background We aimed to build a prediction nomogram for early prediction of poor prognosis in children with Escherichia coli meningitis and analyzed the course of treatment and discharge criteria. Methods Eighty-seven pediatric patients with E coli meningitis were retrospectively recruited from the Children's Hospital of Chongqing Medical University between June 2012 and November 2021. Univariate analysis and binary logistic analysis were used to evaluate the risk factors, and the prediction model was built. Results E coli meningitis is more common in children <3 months old in our study (86.2%). Common complications were subdural effusion (39.1%), followed by hydrocephalus (13.8%) and repeated convulsions (12.6%). The mortality rate and sequelae rate of E coli meningitis in children was & SIM;10.9% and & SIM;6.3%, respectively. Univariate analysis showed that 13 clinical indicators were associated with poor prognosis of E coli meningitis in children. In binary logistic analysis, risk factors were seizures (P = .032) and the last cerebrospinal fluid glucose content before discharge (P = .002). A graphical nomogram was designed. The area under the receiver operating characteristic curve was 0.913. The Hosmer-Lemeshow test showed that the model was a good fit (P = .648). Internal validation proved the reliability of the prediction nomogram. Conclusions E coli meningitis is more common in children E coli meningitis by clinicians."

基金机构：　

基金资助正文：