Prognostic value of preoperative prealbumin levels in patients with unresectable hepatocellular carcinoma undergoing transcatheter arterial chemoembolisation

作者全名："Lei, Kai; Wang, Jia -Guo; Li, Yin; Wang, Hong-Xiang; Xu, Jie; You, Ke; Liu, Zuo-Jin"

作者地址："[Lei, Kai; Wang, Jia -Guo; Li, Yin; Wang, Hong-Xiang; Xu, Jie; You, Ke; Liu, Zuo-Jin] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400000, Peoples R China"

通信作者："Liu, ZJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400000, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001048853200001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：Hepatocellular carcinoma (HCC); OS (overall survival); Prealbumin (PAB); Prognosis; Transcatheter arterial chemoembolisation (TACE)

摘要："Background: This retrospective study analyzed the prognostic value of preoperative prealbumin (PAB) levels in patients with unresectable hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolisation (TACE). Methods: Four hundred and two patients diagnosed with unresectable HCC were included in this retrospective study. All patients underwent their first TACE procedure. Based on PAB levels before the first TACE, 402 patients were classified as having low PAB levels and high PAB levels. Potential confounding factors between the two groups were eliminated using. Propensity Score Matching (PSM) analysis. The time to progression (TTP) and overall survival (OS) of the two groups were compared using Kaplan-Meier curves before and after PSM. Risk factors for poor prognosis were determined using univariate and multivariate Cox proportional hazards models. Results: Before PSM, the high PAB level group had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.0001). After PSM, the high PAB level group still had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.05). After PSM, low PAB level was found to be an independent predictor of shorter OS (HR = 0.656; 95% CI:0.448-0.961; P = 0.03). The subgroup analysis before PSM showed that low PAB levels increased the risk of poor prognosis in most subgroups. Conclusions: Low preoperative PAB levels are associated with poor prognosis in patients with unresectable HCC after TACE."

基金机构：National Natural Science Foundation of China [82070678]; Chongqing Medical Uni-versity Program for Youth Innovation in Future Medicine [W0084]

基金资助正文：This work was supported by the National Natural Science Foundation of China (No.82070678) and the Chongqing Medical Uni-versity Program for Youth Innovation in Future Medicine (grant number W0084) .