A parabrachial-hypothalamic parallel circuit governs cold defense in mice

作者全名："Yang, Wen Z.; Xie, Hengchang; Du, Xiaosa; Zhou, Qian; Xiao, Yan; Zhao, Zhengdong; Jia, Xiaoning; Xu, Jianhui; Zhang, Wen; Cai, Shuang; Li, Zhangjie; Fu, Xin; Hua, Rong; Cai, Junhao; Chang, Shuang; Sun, Jing; Sun, Hongbin; Xu, Qingqing; Ni, Xinyan; Tu, Hongqing; Zheng, Ruimao; Xu, Xiaohong; Wang, Hong; Fu, Yu; Wang, Liming; Li, Xi; Yang, Haitao; Yao, Qiyuan; Yu, Tian; Shen, Qiwei; Shen, Wei L."

作者地址："[Yang, Wen Z.; Xie, Hengchang; Du, Xiaosa; Zhou, Qian; Xiao, Yan; Zhao, Zhengdong; Jia, Xiaoning; Li, Zhangjie; Fu, Xin; Cai, Junhao; Chang, Shuang; Sun, Jing; Sun, Hongbin; Ni, Xinyan; Tu, Hongqing; Yang, Haitao; Shen, Wei L.] Shanghaitech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; [Yang, Wen Z.; Xie, Hengchang; Du, Xiaosa; Zhou, Qian; Xiao, Yan; Zhao, Zhengdong; Jia, Xiaoning; Li, Zhangjie; Fu, Xin; Cai, Junhao; Chang, Shuang; Sun, Jing; Sun, Hongbin; Ni, Xinyan; Tu, Hongqing; Yang, Haitao; Shen, Wei L.] Shanghaitech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Xie, Hengchang; Zhou, Qian; Zhang, Wen; Xu, Xiaohong] Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China; [Xie, Hengchang; Zhou, Qian] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Xu, Jianhui; Yu, Tian] Chengdu Med Coll, Thermoregulat & Inflammat Lab, Chengdu 610500, Sichuan, Peoples R China; [Cai, Shuang; Yu, Tian] Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi 563006, Peoples R China; [Hua, Rong; Yao, Qiyuan; Shen, Qiwei] Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China; [Xu, Qingqing; Li, Xi] Chongqing Med Univ, Inst life Sci, Chongqing 400044, Peoples R China; [Zheng, Ruimao] Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100871, Peoples R China; [Zheng, Ruimao] Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China; [Wang, Hong] Chinese Acad Sci, Brain Cognit & Brain Dis Inst BCBDI, Shenzhen Inst Adv Technol, Beijing, Peoples R China; [Wang, Hong] Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundam, Shenzhen 518055, Peoples R China; [Fu, Yu] ASTAR, Inst Mol & Cell Biol, Singapore 138667, Singapore; [Wang, Liming] Inst Mol Physiol, Shenzhen Bay Lab, Shenzhen 518055, Peoples R China"

通信作者："Shen, WL (通讯作者)，Shanghaitech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China.; Yu, T (通讯作者)，Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi 563006, Peoples R China.; Shen, QW (通讯作者)，Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China."

来源：NATURE COMMUNICATIONS

ESI学科分类：　

WOS号：WOS:001051523700017

JCR分区：Q1

影响因子：14.7

年份：2023

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense. Together, these pathways make an equivalent and cumulative contribution, forming a parallel circuit. Specifically, activation of the LPB & RARR; DMH pathway induced strong cold-defense responses, including increases in thermogenesis of brown adipose tissue (BAT), muscle shivering, heart rate, and locomotion. Further, we identified somatostatin neurons in the LPB that target DMH to promote BAT thermogenesis. Therefore, we reveal a parallel circuit governing cold defense in mice, which enables resilience to hypothermia and provides a scalable and robust network in heat production, reshaping our understanding of neural circuit regulation of homeostatic behaviors. The neural mechanisms responsible for cold defense regulation are still unclear. Here, authors show parallel thermogenic pathways from the brain stem to the hypothalamus work together to enable resilience to cold temperature exposure and hypothermia."

基金机构："ShanghaiTech University - National Key Research and Development Program of China [2019YFA0801900]; National Key Research and Development Program of China; National Nature Science Foundation of China [2019YFA0801900]; Shanghai Science and Technology Committee of Shanghai City [32122039, 32100825]; Shanghai Sailing Program [21JC1404900, 21XD1422700]; Shanghai Municipal Education Commission [21YF1429800]; Shanghai Education Development Foundation; Ministry of Science and Technology of China [20CG71]; Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University [2017YFA0205903]; Open Research Fund of State Key Laboratory of Genetic Engineering-Fudan University; Singapore National Medical Research Council [SKLGE-2303]; Singapore National Research Foundation [MOH-000611-00]; [NRF-NRFI07-2021-0001]"

基金资助正文："We thank Drs. Ji Hu, Zhenge Luo for sharing reagents; Dr. Xiaoming Li and the Molecular Imaging Core Facility (MICF) of School of Life Science and Technology, ShanghaiTech University for Microscopic imaging; Dr. Ying Xiong and the Molecular Cellular Core for slices and staining; all Shen lab members for valuable discussion. This study was funded by the National Key Research and Development Program of China (2019YFA0801900), National Nature Science Foundation of China (32122039 to W. Shen; 32100825 to W. Yang), Shanghai Science and Technology Committee of Shanghai City (21JC1404900 and 21XD1422700 to W. Shen), Shanghai Sailing Program (21YF1429800 to W. Yang), ""Chen Guang"" project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (20CG71 to W. Yang), Ministry of Science and Technology of China (2017YFA0205903), Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University, Open Research Fund of State Key Laboratory of Genetic Engineering-Fudan University (SKLGE-2303), and Singapore National Medical Research Council (MOH-000611-00 to Y. Fu) and Singapore National Research Foundation (NRF-NRFI07-2021-0001 to Y. Fu). We thank the staff members of the Animal Facility at ShanghaiTech University for providing technical support and assistance."