ZIF-8 coated gold nanospheres: a multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells
作者全名："Lei, Miao; Cai, Weiye; Zou, Luetao; Yu, Bin; Chen, Lin; Cao, Yang; Xiang, Shanlin; Song, Chao; Lei, Jiandu; Jiang, Wei; Hu, Zhenming"
作者地址："[Lei, Miao; Chen, Lin; Xiang, Shanlin; Jiang, Wei; Hu, Zhenming] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Orthoped Lab, 1 Youyi Rd, Chongqing 400010, Peoples R China; [Cai, Weiye; Song, Chao] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Luzhou 646699, Peoples R China; [Zou, Luetao] Chongqing Med Univ, Affiliated Hosp 3, Dept Orthoped, Chongqing 400010, Peoples R China; [Yu, Bin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400010, Peoples R China; [Chen, Lin] Chongqing Univ, Three Gorges Hosp, Dept Orthoped, Chongqing 404000, Peoples R China; [Cao, Yang] Guizhou Med Univ, Affiliated Hosp, Dept Geriatr, Guiyang 550025, Peoples R China; [Lei, Jiandu] Beijing Forestry Univ, Coll Mat Sci & Technol, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China"
通信作者："Jiang, W; Hu, ZM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Orthoped Lab, 1 Youyi Rd, Chongqing 400010, Peoples R China.; Lei, JD (通讯作者)，Beijing Forestry Univ, Coll Mat Sci & Technol, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China."
来源：NANO RESEARCH
ESI学科分类：PHYSICS
WOS号：WOS:001051575900002
JCR分区：Q1
影响因子：9.5
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：zeolitic imidazolate framework-8 (ZIF-8); gold nanospheres (AuNPs); photothermal therapy (PTT); starvation therapy; ferroptosis
摘要："Photothermal therapy (PTT) has been widely used in the treatment of tumors, but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins (HSPs) caused by high temperature. This article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism. A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase (GOX) and gold nanospheres (AuNPs) loaded with dihydroartemisinin (DHA) with zeolitic imidazolate framework-8 (ZIF-8). This platform can take advantage of the microenvironment of osteosarcoma (OS) cells, featuring low pH and high reactive oxygen species (ROS), for precision drug delivery. GOX can effectively catalyze glucose to produce gluconic acid and H2O2, and DHA can also induce ROS production in OS cells. ROS produced by GOX and DHA can further generate lipid peroxidation (LPO) and lead to ferroptosis of OS cells. At the same time, ROS and LPO produced can inhibit the expression of HSPs, thereby increasing the therapeutic effect of PTT. In vitro experiments show that the nanoparticles are pH and ROS responsive. 1 mu g/mL GOX combined with 0.2 mu g/mL DHA promotes ferroptosis of OS cells, and increases the killing effect of near-infrared (NIR) on OS cells. Further in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS cells. Meanwhile, this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods."
基金机构："National Natural Science Foundation of China [82002363]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0195]"
基金资助正文："This study was supported by the National Natural Science Foundation of China (No. 82002363), Natural Science Foundation of Chongqing, China (No. cstc2020jcyj-msxmX0195). All protocols of the animal study were approved by the Institutional Review Committee of Chongqing Medical University. Thanks to Ms. Xiaoyan Qin and Professor Ziguo Luo for their suggestions and guidance."
