Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder

作者全名："Li, Xuemei; Huang, Yang; Liu, Mengqi; Zhang, Manqi; Liu, Yang; Teng, Teng; Liu, Xueer; Yu, Ying; Jiang, Yuanliang; Ouyang, Xuan; Xu, Ming; Lv, Fajin; Long, Yicheng; Zhou, Xinyu"

作者地址："[Li, Xuemei; Teng, Teng; Liu, Xueer; Jiang, Yuanliang; Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Huang, Yang; Liu, Mengqi; Liu, Yang; Lv, Fajin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Zhang, Manqi; Ouyang, Xuan; Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China; [Zhang, Manqi; Ouyang, Xuan; Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China; [Yu, Ying] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Xu, Ming] Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China; [Xu, Ming] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China; [Xu, Ming] Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China; [Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Renmin Middle Rd, Changsha, Peoples R China; [Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, 139 Renmin Middle Rd, Changsha, Peoples R China; [Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Long, YC (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Renmin Middle Rd, Changsha, Peoples R China.; Long, YC (通讯作者)，Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, 139 Renmin Middle Rd, Changsha, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001053489700001

JCR分区：Q1

影响因子：5.3

年份：2023

卷号：23

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：Childhood trauma; Major depressive disorder; Adolescent; Functional neuroimaging; Brain network

摘要："Childhood trauma is a leading risk factor for adolescents developing major depressive disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This study aimed to investigate the association among childhood trauma, MDD and brain dysfunctions by combining static and dynamic brain network models. We recruited 46 first-episode drug-naive adolescent MDD patients with childhood trauma (MDD-CT), 53 MDD patients without childhood trauma (MDD-nCT), and 90 healthy controls (HCs) for resting-state functional magnetic resonance imaging (fMRI) scans; all participants were aged 13-18 years. Compared to the HCs and MDD-nCT groups, the MDD-CT group exhibited significantly higher global and local efficiency in static brain networks and significantly higher temporal correlation coefficients in dynamic brain network models at the whole-brain level, and altered the local efficiency of default mode network (DMN) and temporal correlation coefficients of DMN, salience (SAN), and attention (ATN) networks at the local perspective. Correlation analysis indicated that altered brain network features and clinical symptoms, childhood trauma, and particularly emotional neglect were highly correlated in adolescents with MDD. This study may provide new evidence for the dysconnectivity hypothesis regarding the associations between childhood trauma and MDD in adolescents from the perspectives of both static and dynamic brain topology."

基金机构："STI2030-Major Projects [82271565]; National Natural Science Foundation of China [82201692, cstc2020jcyj-jqX0024]; Chongqing Outstanding Youth Foundation; [2022ZD0212900]"

基金资助正文："This work was supported by the STI2030-Major Projects (2022ZD0212900 to XZ) , the National Natural Science Foundation of China (82271565 to XZ, 82201692 to YL) and Chongqing Outstanding Youth Foundation (cstc2020jcyj-jqX0024 to XZ) ."