Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults

作者全名："Xiao, Yi; He, Hongmei; Xiang, Ling; Gu, Haitao; Xu, Zhiquan; Luo, Haoyun; Ren, Xiaorui; Li, Bo; Wei, Qi; Zhu, Zhiyong; Zhou, He; Tang, Yunhao; Zhou, Zhihang; Peng, Linglong; Wang, Yaxu; Jiang, Yahui"

作者地址："[Xiao, Yi; He, Hongmei; Gu, Haitao; Xu, Zhiquan; Luo, Haoyun; Ren, Xiaorui; Li, Bo; Wei, Qi; Zhu, Zhiyong; Tang, Yunhao; Peng, Linglong; Wang, Yaxu; Jiang, Yahui] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China; [Xiang, Ling] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, Chongqing, Peoples R China; [Zhou, He] Univ Oxford, Dept Oncol, Lab Canc Biol, Oxford, England; [Zhou, He] North Sichuan Med Coll, Affiliated Hosp, Dept Gastrointestinal Surg 2, Nanchong, Peoples R China; [Zhou, Zhihang] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Chongqing, Peoples R China"

通信作者："Wang, YX; Jiang, YH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001055032300001

JCR分区：Q2

影响因子：4

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：sulfur microbial diet; colorectal cancer precursors; cancer prevention; epidemiology; dietary pattern

摘要："Background: Sulfur microbial diet (SMD), related to the enrichment of sulfur-metabolizing gut bacteria, has been confirmed to be linked to an elevated risk of early-onset colorectal adenoma in young females. However, it remains unclear whether SMD is associated with the risk of colorectal adenoma in older people, who are at greater risk for colorectal cancer.Methods: All data on participants in this study were retrieved from the intervention arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening test. Participants' adherence to this dietary pattern was assessed using SMD score. Hazard ratios (HR) and 95% confidence intervals (CI) were adopted in Cox proportional hazards regression models to assess the link between SMD score and the incidence of colorectal adenoma in participants included in the study. Specific stratified analyses were constructed to assess whether this association changed in different conditions, whereas the robustness of the association was examined through sensitivity analyses.Results: The mean baseline age of participants was 62.1 (SD 5.2) years (range 54.0-75.0 years). During 19,468,589 person-years of follow-up, 992 colorectal adenoma cases were documented in a total of 17,627 included participants. In a fully adjusted model, an increased risk of colorectal adenoma was determined in participants in the highest quartile of SMD score in comparison with those in the lowest quartile (HR(quartile)4 vs. HRquartile1 = 1.23; 95% CI: 1.02, 1.47; p = 0.017 for trend). This positive association between SMD score and adenoma risk was more evident in participants who were current or former smokers (p = 0.029 for interaction).Conclusion: In this study, our results support a role for the SMD in the carcinogenicity of colorectal cancer precursors among older adults. Nevertheless, these results require validation through more research."

基金机构："This work was supported by the General Project of Chongqing Natural Science Foundation, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153 (LP)], [cstc2021jcyj-msxmX0112 (YW)], and [CSTB2022NSCQ-MSX1005 (HG)], and Kuanren Talents Pr; General Project of Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0112, CSTB2022NSCQ-MSX1005, kryc-yq-2110]; Chongqing Science and Technology Commission, China; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China; [cstc2021jcyj-msxmX0153]"

基金资助正文："This work was supported by the General Project of Chongqing Natural Science Foundation, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153 (LP)], [cstc2021jcyjmsxmX0112 (YW)], and [CSTB2022NSCQ-MSX1005 (HG)], and Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110 (HG)]. The funders had no role in the study design or implementation; data collection, management, analysis or interpretation; manuscript preparation, review or approval; or the decision to submit the manuscript for publication."