TUG-891 inhibits neuronal endoplasmic reticulum stress and pyroptosis activation and protects neurons in a mouse model of intraventricular hemorrhage

作者全名："Wang, Hao-Xiang; Liu, Chang; Li, Yuan-You; Cao, Yi; Zhao, Long; Zhao, Yan-Jie; Deng, Zi-Ang; Tong, Ai-Ping; Zhou, Liang-Xue"

作者地址："[Wang, Hao-Xiang; Li, Yuan-You; Zhao, Yan-Jie; Deng, Zi-Ang; Tong, Ai-Ping; Zhou, Liang-Xue] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China; [Liu, Chang] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China; [Cao, Yi] Chengdu Second Peoples Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China; [Zhao, Long] North Sichuan Med Coll, Affiliated Hosp, Dept Neurosurg, Nanchong, Sichuan, Peoples R China; [Tong, Ai-Ping] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China"

通信作者："Tong, AP; Zhou, LX (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China.; Tong, AP (通讯作者)，Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China."

来源：NEURAL REGENERATION RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001058059000034

JCR分区：Q1

影响因子：5.9

年份：2023

卷号：18

期号：10

开始页：2278

结束页：2284

文献类型：Article

关键词：ameliorating inflammation; endoplasmic reticulum stress; GPR120; GSDMD; hemorrhagic stroke; neurological function; NLRP3; pyroptosis; TUG-891; unfolded protein response

摘要："Pyroptosis plays an important role in hemorrhagic stroke. Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) pathway. However, the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear. In this study, we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue. Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress, pyroptosis, and inflammation and protected neurons. The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation."

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