Self-directed physical activity interventions for motor symptoms and quality of life in early and mid-stage Parkinson's disease: A systematic review and meta-analysis

作者全名："Li, Hanzhang; Cao, Chunhao; Li, Yanan"

作者地址："[Li, Hanzhang; Li, Yanan] Hubei Univ Chinese Med, Wuhan, Peoples R China; [Cao, Chunhao] Chongqing Med Univ, Affiliate Hosp 1, Dept Integrated Tradit Chinese & Western Med, Chongqing, Peoples R China; [Li, Yanan] Hubei Univ Chinese Med, POB 430065, Wuhan, Peoples R China"

通信作者："Li, YN (通讯作者)，Hubei Univ Chinese Med, POB 430065, Wuhan, Peoples R China."

来源：ARCHIVES OF GERONTOLOGY AND GERIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001066831600001

JCR分区：Q2

影响因子：4

年份：2024

卷号：116

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Self -directed physical activity; Motor symptoms; Quality of life; Parkinson's disease; Systematic review; Meta -analysis

摘要："Background: Self-directed physical activity (SDPA) has been found in previous research to alleviate some of the symptoms of early and mid-stage Parkinson's disease (PD) patients. So, this study aimed to determine the impact of SDPA on these patients in the areas of motor symptoms, and quality of life (QoL).Method: PubMed, Embase, the Cochrane Library, the Web of Science, Scopus, and ProQuest were all searched. The risk-of-bias tool of Cochrane for randomized trials, Version 2 (RoB 2), was also used to assess the credibility of studies in terms of their procedures.Results: 15 eligible studies were analyzed. SDPA improved motor function and mobility, including timed up and go (TUG) test [standardized mean difference (SMD), -0.55 (95% CI, -0.91 - -0.18), p = 0.003], 6-minute walking (6MW) test [1.11 (0.75 - 1.47), p < 0.00001], stride length [0.45 (0.18 - 0.72), p = 0.001], gait velocity [0.42 (0.04 - 0.81 p = 0.03], Unified Parkinson's Disease Rating Scale Part-III (UPDRS-III) [-0.76 (-1.18 - - 0.33), p = 0.0005] and enhanced Berg Balance Scale (BBS) [0.88 (0.50 - 1.27), p < 0.00001]). Despite engaging in SDPA, there was no significant improvement observed in freezing of gait (FOG) [0.23 (-0.11 - 0.56), p = 0.18] as well as the Parkinson's Disease Questionnaire-39 (PDQ-39) [0.04 (-0.55 - 0.62), p = 0.90]).Conclusion: The motor symptoms of those with early to mid-stage PD improved with SDPA, however the research found no enhancement in FOG or QoL."

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