Autoimmune encephalitis antibody profiles and clinical characteristics of children with suspected autoimmune encephalitis

作者全名："Yang, Jiaxin; Luo, Hanyu; Ding, Ran; Fang, Zhixu; Gui, Jianxiong; Han, Ziyao; Yang, Xiaoyue; Huang, Dishu; Ma, Jiannan; Jiang, Li"

作者地址："[Yang, Jiaxin; Luo, Hanyu; Ding, Ran; Fang, Zhixu; Gui, Jianxiong; Han, Ziyao; Yang, Xiaoyue; Huang, Dishu; Ma, Jiannan; Jiang, Li] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Dept Neu, Chongqing, Peoples R China; [Ma, Jiannan; Jiang, Li] Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Ma, JN; Jiang, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001073874200001

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

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摘要："AimTo identify the spectrum of autoimmune encephalitis antibody biomarkers (AE-Abs) in children with suspected autoimmune encephalitis and explore the clinical features indicating AE-Abs presence.MethodWe included children with suspected autoimmune encephalitis who underwent AE-Abs tests at the Children's Hospital of Chongqing Medical University between June 2020 and June 2022. Clinical features suggestive of AE-Abs were analysed based on AE-Abs test results.ResultsA total of 392 children were tested for AE-Abs with suspected autoimmune encephalitis. Of these, 49.5% were male, with a median age of 7 years 11 months (6 months-17 years 11 months); 93.6% (367/392) of all patients had both serum and cerebrospinal fluid (CSF) tests performed. The antibody-positive rate in the cohort was 23.7% (93/392), the serum antibody-positive rate was 21.9% (84/384), and the CSF antibody-positive rate was 20.8% (78/375). Eleven different AE-Abs were detected. Serum analysis revealed that N-methyl-D-aspartate receptor immunoglobulin-G (NMDAR-IgG) (15.1%) was greater than myelin oligodendrocyte glycoprotein (MOG)-IgG (14.6%) and glial fibrillary acidic protein (GFAP)-IgG (3.3%). CSF analysis revealed that NMDAR-IgG (16.3%) was greater than MOG-IgG (13.8%) and GFAP-IgG (3.3%). Compared with antibody-negative patients, antibody-positive patients were more often female (odds ratio [OR] 1.86, p = 0.03), with memory impairment (OR 2.91, p = 0.01) and sleep disorders (OR 2.08, p = 0.02).InterpretationIn children, the most frequent AE-Abs detected were NMDAR-IgG and MOG-IgG. Female sex, memory impairment, and sleep disorders predict a higher likelihood of AE-Abs. image"

基金机构：The authors declare that no commercial or financial relationships that could be construed as potential conflicts of interest existed during the research.

基金资助正文："This work was supported by the National Clinical Research Centre for Child Health and Disorders (grant number NCRCCHD-2022-YP-08).r The data supporting the study & apos;s findings are available upon request from the corresponding author. Because of privacy or ethical concerns, the data is not publicly available.r We gratefully acknowledge the assistance of the Chongqing Higher Institution Engineering Research Centre of Children & apos;s Medical Big Data Intelligent Application in data collection.r The authors declare that no commercial or financial relationships that could be construed as potential conflicts of interest existed during the research."