Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer

作者全名："Qiu, Heping; Wang, Jianwu; Zhi, Yi; Yan, Benhuang; Huang, Yuandi; Li, Jinjin; Shen, Chongxing; Dai, Linyong; Fang, Qiang; Shi, Chunmeng; Li, Weibing"

作者地址："[Qiu, Heping; Wang, Jianwu; Zhi, Yi; Yan, Benhuang; Huang, Yuandi; Li, Jinjin; Shen, Chongxing; Dai, Linyong; Fang, Qiang; Li, Weibing] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Shi, Chunmeng] Army Med Univ, Mil Med Univ 3, Inst Rocket Force Med, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China"

通信作者："Fang, Q; Li, WB (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 3, Chongqing 401120, Peoples R China.; Shi, CM (通讯作者)，Army Med Univ, Mil Med Univ 3, Inst Rocket Force Med, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001074974600001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：15

期号：40

开始页：46668

结束页：46680

文献类型：Article

关键词：bladder cancer; polydopamine; targeting; imaging; intravesical chemotherapy

摘要："Bladder cancer is one of the most common malignancies in the urinary system, with high risk of recurrence and progression. However, the difficulty in detecting small tumor lesions and the lack of selectivity of intravesical treatment seriously affect the prognosis of patients with bladder cancer. In the present work, a nanoparticle-based delivery system with tumor targeting, high biocompatibility, simple preparation, and the ability to synergize imaging and therapy was fabricated. Specifically, this nanosystem consisted of the core of doxorubicin (DOX)-loaded polydopamine nanoparticles (PDD NPs) and the shell of hyaluronic acid (HA)-conjugated IR780 (HA-IR780). The HA-IR780-covered PDD NPs (HR-PDD NPs) demonstrated tumor targeting and visualization both in vitro and in vivo with properties of promoted cancer cell endocytosis and lysosomal escape, efficiently delivering drugs to the target site and exerting a killing effect on tumor cells. Encouragingly, intravesical instillation of HR-PDD NPs improved drug retention in the bladder and promoted its accumulation in tumor tissue, resulting in better tumor proliferation inhibition and apoptosis in an orthotopic bladder cancer model in rats. This study provides a promising strategy for the diagnosis and therapy of bladder cancer."

基金机构：Outstanding Scientist Program of Chongqing Talent Plan [CQYC20200101159]

基金资助正文：This work was supported by the Outstanding Scientist Program of Chongqing Talent Plan (CQYC20200101159).