Altered EEG Microstates Dynamics in Individuals with Subthreshold Depression When Generating Negative Future Events

作者全名："Yang, Zhuoya; Xia, Lei; Fu, Yixiao; Zheng, Yingcan; Zhao, Mengxue; Feng, Zhengzhi; Shi, Chunmeng"

作者地址："[Yang, Zhuoya] Army Med Univ, Sch Med Psychol, Dept Basic Psychol, Chongqing 400038, Peoples R China; [Xia, Lei] Army Med Univ, Expt Res Ctr Med & Psychol Sci, Sch Med Psychol, Chongqing 400038, Peoples R China; [Fu, Yixiao] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China; [Zheng, Yingcan] Army Med Univ, Sch Med Psychol, Dept Dev Psychol Armyman, Chongqing 400038, Peoples R China; [Zhao, Mengxue] Army Med Univ, Sch Psychol, Dept Mil Psychol, Chongqing 400038, Peoples R China; [Yang, Zhuoya; Xia, Lei; Zheng, Yingcan; Zhao, Mengxue; Feng, Zhengzhi] Army Med Univ, Sch Med Psychol, 30 Gaotanyan St, Chongqing 400038, Peoples R China; [Shi, Chunmeng] Army Med Univ, Inst Rocket Force Med, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China"

通信作者："Feng, ZZ (通讯作者)，Army Med Univ, Sch Med Psychol, 30 Gaotanyan St, Chongqing 400038, Peoples R China.; Shi, CM (通讯作者)，Army Med Univ, Inst Rocket Force Med, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China."

来源：BRAIN TOPOGRAPHY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001077159500001

JCR分区：Q3

影响因子：2.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Subthreshold depression; Prospection; EEG microstate; Temporal dynamic; Source analysis

摘要："Negative bias in prospection may play a crucial role in driving and maintaining depression. Recent research suggests abnormal activation and functional connectivity in regions of the default mode network (DMN) during future event generation in depressed individuals. However, the neural dynamics during prospection in these individuals remain unknown. To capture network dynamics at high temporal resolution, we employed electroencephalogram (EEG) microstate analysis. We examined microstate properties during both positive and negative prospection in 35 individuals with subthreshold depression (SD) and 35 controls. We identified similar sets of four canonical microstates (A-D) across groups and conditions. Source analysis indicated that each microstate map partially overlapped with a subsystem of the DMN (A: verbal; B: visual-spatial; C: self-referential; and D: modulation). Notably, alterations in EEG microstates were primarily observed in negative prospection of individuals with SD. Specifically, when generating negative future events, the coverage, occurrence, and duration of microstate A increased, while the coverage and duration of microstates B and D decreased in the SD group compared to controls. Furthermore, we observed altered transitions, particularly involving microstate C, during negative prospection in the SD group. These altered dynamics suggest dysconnectivity between subsystems of the DMN during negative prospection in individuals with SD. In conclusion, we provide novel insights into the neural mechanisms of negative bias in depression. These alterations could serve as specific markers for depression and potential targets for future interventions."

基金机构：This work was supported by a grant from the National Natural Science Foundation of China (82101604). [82101604]; National Natural Science Foundation of China

基金资助正文：This work was supported by a grant from the National Natural Science Foundation of China (82101604).