Diagnostic performance of resting full-cycle ratio in identifying coronary lesions causing myocardial ischaemia: a meta-analysis

作者全名："Luo, Yue; Mao, Min; Wu, Fan; Ma, Kanghua; Chang, Jing; Xiang, Rui"

作者地址："[Luo, Yue; Mao, Min; Wu, Fan; Ma, Kanghua; Chang, Jing; Xiang, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China; [Xiang, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Xiang, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：ACTA CARDIOLOGICA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001080700400001

JCR分区：Q3

影响因子：2.1

年份：2023

卷号：78

期号：10

开始页：1103

结束页：1109

文献类型：Article

关键词：Resting full-cycle ratio; fractional flow reserve; coronary artery disease; diagnostic performance

摘要："BackgroundThe resting full-cycle ratio (RFR), a new non-congestive resting index, is commonly used for physiological evaluations of coronary arteries.AimsThis study aims to evaluate the accuracy of RFR in detecting coronary artery stenosis with hemodynamic significance using fractional flow reserve (FFR) as the reference standard.MethodsUsing 'RFR, resting full-cycle ratio' as the search term, we searched PubMed, Embase, Cochrane Library, and Web of Science databases, screening the literature according to the inclusion and exclusion criteria. By applying FFR <= 0.80 and RFR <= 0.89 as the diagnostic criteria for ischaemia, we analysed the synthetic sensitivity, specificity, and corresponding 95% confidence intervals, then synthesised the summary receiver operating characteristic curve (SROC).ResultsThree studies were included in this meta-analysis, comprising 1,084 patients with 1,312 lesions. When we used FFR <= 0.80 as the reference standard, the synthesised sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) of RFR in the diagnosis of coronary ischaemia were 73%, 81%, 67%, 85%, 3.95, and 0.33, respectively. Besides, the area under the curve (AUC) was 0.8276.ConclusionUsing FFR as the reference standard, RFR has good diagnostic accuracy in detecting coronary ischaemic lesions and may be an effective alternative to FFR in the future, to some extent."

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